Phosphine and Sugars enable analysis of glycan biosynthesis.

Press Release Summary:

Allowing sensitive and selective characterization of glycan biosynthesis, Glycoprofile(TM) FLAG® Phosphine and azido labeled sugars utilize modified Staudinger ligation chemistry bio-orthogonal approach to explore glycoprotein metabolism. GlycoProfile FLAG-Phosphine and azido sugars Man-Naz, Glc-Naz, and Gal-Naz enable systemic incorporation in carbohydrate synthesis. Each component is available separately, allowing for flexibility in user-defined applications.

Original Press Release:

Sigma-Aldrich Launches Glycoprofile Flag-Phosphine and New Azido Labeled Sugars

Researchers recognize potential healthcare breakthroughs with glycomics

ST. LOUIS, Aug. 9 / - Sigma-Aldrich (NASDAQ:SIAL) is pleased to announce launch of the Glycoprofile(TM) FLAG® Phosphine and new azido labeled sugars, enabling highly sensitive and selective characterization of glycan biosynthesis. The technology employs a modified-Staudinger ligation chemistry providing a unique and powerful bio-orthogonal approach to explore glycoprotein metabolism.

Effective methods to track synthesis and characterize carbohydrate moieties in model organisms is a well recognized need in the biomarker discovery community. Glycans are responsible for much of the structural variation in biologic systems, and their representation within and on cell surfaces is commonly called the "glycome."

"Researchers increasingly recognize the potential for breakthroughs in healthcare through glycomics by studying carbohydrates, their supporting proteins and respective interactions," said George Lipscomb, Market Segment Manager for Proteomics.

The GlycoProfile FLAG-Phosphine and azido-sugars Man-Naz, Glc-Naz and Gal-Naz enable systemic incorporation in carbohydrate synthesis. Subsequent labeling and detection employs the extensive FLAG platform of complementary reagents available through Sigma-Aldrich. Each component is available separately allowing for flexibility in user defined applications.

About Sigma-Aldrich:
Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. We have customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 36 countries and has 7,700 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer Success through Leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit our award-winning Web site at

Source: Sigma-Aldrich

CONTACT:Sean Battles of Sigma-Aldrich, +1-314-286-7616,

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