Immunodepletion Kit helps identify low abundance proteins.
Press Release Summary:
ProteoPrep® 20 Plasma Immunodepletion Kit removes 99% of 20 high abundant plasma proteins using multivalent antibody affinity media in spin column format, resulting in removal of 97% of overall protein mass. High-density media provides ability to use standard analysis technology to visualize low abundance proteins in plasma proteome,
which are mediators of disease or drug efficacy.
Original Press Release:
Sigma Launches Human Plasma Depletion Technology for Proteomics and Human Disease Biomarker Discovery
ST. LOUIS, Mo., Jan. 25 -- One of the most significant challenges facing scientists in clinical proteomics is the inability to detect the majority of low abundance proteins in plasma, which are the mediators of disease or drug efficacy. Sigma, a division of Sigma- Aldrich Corp. (NASDAQ:SIAL), introduces the new ProteoPrep® 20 Plasma Immunodepletion Kit. The patent pending ProteoPrep 20 Kit removes 99% of twenty high abundant plasma proteins using a proprietary multivalent antibody affinity media in a convenient spin column format resulting in removal of 97% of the overall protein mass. The unique high-density antibody affinity media enhances the ability to visualize low abundance proteins in the plasma proteome using standard analysis technology. Additionally, the multivalent antibody resin utilizes novel recombinant antibodies that allow for a significantly higher density of conjugation and hence, efficiency of depletion with minimal sample loss or dilution. Sigma has developed the technology in cooperation with leading scientists in proteomics and through knowledge gained as a participant in the Human Proteome Organisation (HUPO) Plasma Proteome Project.
"The innovative depletion technology greatly enables deeper penetration into the plasma proteome and will facilitate the discovery of new potential biomarkers in cancer research and many other areas using proteome analysis", said Michael Pisano, President and Co-Founder of Proteomic Research Services, a proteomics services company in Ann Arbor, Michigan. "We have been able to show that after depletion with the ProteoPrep 20 Kit, proteins can be identified that were previously not detected from either whole plasma or following depletion with standard tools."
"The launch of the ProteoPrep 20 Plasma Immunodepletion Kit significantly improves the capabilities of our customers in the proteomics area to visualize and analyze very low expressed proteins", commented George Lipscomb, Product Manager, Proteomics at Sigma-Aldrich. "It exemplifies our commitment to provide innovative solutions and our capability to develop new products in a close relationship with out customers and the scientific community. The ProteoPrep Kit is clearly a result of Sigma working with our customers and addressing their needs."
For more information on the ProteoPrep 20 Immunodepletion Kit from Sigma- Aldrich, please visit us online at http://sigma-aldrich.com/p20.
Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. We have customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use their products. Sigma-Aldrich operates in 35 countries and has 6,800 employees providing excellent service worldwide. We are committed to accelerating Customers' success through leadership in Life Science, High Technology and Service. For more information about Sigma- Aldrich, please visit its award-winning web site at http://sigma-aldrich.com/.
CONTACT: Michael Hadjisavas of Sigma-Aldrich Corp., +1-314-286-7431
Web site: http://www.sigma-aldrich.com/
