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Sigma Life Science Licenses CompoZr Zinc Finger Nuclease Technology to Horizon Discovery

Original Press Release

Sigma Life Science Licenses CompoZr Zinc Finger Nuclease Technology to Horizon Discovery

Press release date: September 3, 2013

Horizon to utilize both nuclease and rAAV gene editing platforms in custom cell-line generation services and creation of genetically-defined cell line products

ST. LOUIS  -- Sigma-Aldrich® Corporation (Nasdaq: SIAL) today announced that Sigma® Life Science, its innovative biological products and services business, has entered a non-exclusive license agreement with Horizon Discovery for use of Sigma's CompoZr® Zinc Finger Nuclease (ZFN) technology. The agreement gives Horizon the commercial freedom to apply the technology alongside its proprietary rAAV technology in its gene-editing service and cell line product business units.

Horizon will immediately begin applying the CompoZr ZFN technology as part of its custom cell line generation service, in which the company currently uses its own rAAV technology, to efficiently and cost-effectively generate a number of novel gene-edited cell lines. The offering will be marketed under Horizon's precision gene-editing brand GENESIS™.

"Licensing CompoZr ZFN technology to Horizon is another step in making the most robust and flexible gene editing technology widely available to the entire research community," said Paul Brooks, Ph.D., Global Market Segment Manager at Sigma-Aldrich. "We are pleased that Horizon will be using its expertize to apply both rAAV and CompoZr ZFN gene editing technologies side by side for the benefit of the research community."

"Nuclease based approaches are particularly adept at achieving rapid and efficient knock-out of two or more alleles, making them a perfect complement to Horizon's proprietary rAAV-based precision gene-editing platform," said Eric Rhodes, Chief Technology Officer of Horizon who has 15 years of experience in ZFN and rAAV gene-editing technology. "Our scientists have the expertise and now an unrivalled toolset to help guide customers toward the approach that best answers their biological question and/or suits their timescale and budget."

Under the terms of the deal, Horizon will obtain CompoZr ZFNs manufactured by Sigma Life Science for use in commercial development of cell-based products and to provide commercial gene editing services. Financial terms were not disclosed.

About Sigma Life Science: Sigma Life Science is a Sigma-Aldrich business that represents the Company's leadership in innovative biological products and services for the global life science market and offers an array of biologically-rich products and reagents that researchers use in scientific investigation. Product areas include biomolecules, genomics and functional genomics, cells and cell-based assays, transgenics, protein assays, stem cell research, epigenetics and custom services/oligonucleotides. Sigma Life Science also provides an extensive range critical bioessentials like biochemicals, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, amino acids and their derivatives, and cell culture media.

About Sigma-Aldrich: Sigma-Aldrich, a leading Life Science and High Technology company focused on enhancing human health and safety, manufactures and distributes more than 200,000 chemicals, biochemicals and other essential products to more than 1.4 million customers globally in research and applied labs as well as in industrial and commercial markets. With three distinct business units - Research, Applied and SAFC Commercial - Sigma-Aldrich is committed to enabling science to improve the quality of life. The Company operates in 38 countries, has more than 9,000 employees worldwide and had sales of $2.6 billion in 2012. For more information about Sigma-Aldrich, please visit its website at www.sigma-aldrich.com.

SOURCE Sigma-Aldrich Corporation

CONTACT: FORWARD INQUIRIES TO: Sigma-Aldrich, Jen McMahon, + (1) 314-236-0986, jen.mcmahon@sial.com, Media Inquiries: Harris D. McKinney, Inc, Alan Zachary, Ph.D., + (1) 312-506-5220, azachary@harrisdmckinney.com, Ryan Ferrell, + (1) 312-506-5202, rferrell@harrisdmckinney.com

Web Site: http://www.sigma-aldrich.com

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