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Proposed ASTM Standard aims to aid antimicrobial development.

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January 26, 2011 - Proposed standard ASTM WK30842, Test Method for Serial Passage Resistance Induction to Assess the Potential for Bacteria to Develop Resistance to an Antimicrobial Compound, is under jurisdiction of Subcommittee E35.15 on Antimicrobial Agents. If approved, it could be used by pharmaceutical manufacturers as well as antiseptic and sanitizer manufacturers during development of new topical formulations to provide reproducible way of evaluating potential for antimicrobial compounds.

Potential for Stronger Microbial Populations Leads to Proposed New ASTM Resistance Induction Standard

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ASTM International
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Press release date: January 21, 2011

W. CONSHOHOCKEN, Pa.-As the use of antimicrobial agents in both medical and consumer settings continues to grow, there is real concern that targeted and peripheral microbial populations will develop survival strategies that would make them harder to eradicate when found in disease or spoilage situations.

According to J. Stephen Richards, a research fellow at Johnson & Johnson and a member of ASTM International Committee E35 on Pesticides and Alternative Control Agents, a proposed new ASTM method will provide a reproducible way to evaluate the potential for antimicrobial compounds to drive development of stronger microbial populations that are no longer affected by the antimicrobial. This new method will allow routine monitoring of this potential across time and geographic barriers.

The proposed new standard, ASTM WK30842, Test Method for Serial Passage Resistance Induction to Assess the Potential for Bacteria to Develop Resistance to an Antimicrobial Compound, is under the jurisdiction of Subcommittee E35.15 on Antimicrobial Agents.

Once approved, the standard could be used by pharmaceutical manufacturers, as well as antiseptic and sanitizer manufacturers, during the development of new topical formulations. The primary value of the proposed standard, however, will be for independent test laboratories responsible for demonstrating a formulation's antimicrobial qualities in support of label claims. All interested parties are invited to participate in the standards developing activities of E35.15.

"The mandate of E35.15 is the development of standard methods for testing the effectiveness of chemical formulations and devices that are intended to have antibacterial, antifungal and/or antiviral activity topically or as sanitizers/disinfectants/sterilants," says John Mitchell, Bioscience Laboratories Inc., and chairman of the subcommittee.

"If shown to be effective according to the testing, such products have enormous importance in the healthcare and food service industries, as well as for the general public, in the prevention of disease."

To purchase ASTM standards, visit and search by the standard designation number, or contact ASTM Customer Relations (phone: 610-832-9585; ASTM International welcomes and encourages participation in the development of its standards. For more information on becoming an ASTM member, visit

ASTM International is one of the largest international standards development and delivery systems in the world. ASTM International meets the World Trade Organization (WTO) principles for the development of international standards: coherence, consensus, development dimension, effectiveness, impartiality, openness, relevance and transparency. ASTM standards are accepted and used in research and development, product testing, quality systems and commercial transactions.

View this release on the ASTM Web site at

ASTM Committee E35 Next Meeting: April 11-14, 2011, April Committee Week, Anaheim, Calif. Technical Contact: J. Stephen Richards, Johnson & Johnson, Skillman, N.J., Phone: 908-874-1424; ASTM Staff Contact: Jennifer Rodgers, Phone: 610-832-9694; ASTM PR Contact: Barbara Schindler, Phone: 610-832-9603;
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