Fragment Library accelerates drug discovery lead generation.

Press Release Summary:

Conserving time related to sample and stock solution preparation, Maybridge Ro3 Diversity Fragment Library is available in ready-to-use format. Available in three 500-compound sets, each compound in library is pre-solubilized as 1 mL 10 mM solution, providing 10 µMol of 95% purity pharmacophore dissolved in analytical grade DMSO. Of 1,500 compounds, many are Maybridge-exclusive small-molecule pharmacophores. Automation-compatible matrix tube and latch-rack formats are available.

Original Press Release:

Thermo Fisher Scientific Introduces "Off the Shelf" Fragment Library for Time-Efficient Drug Discovery Lead Generation

Maybridge Ro3 Diversity Fragments now available in prepared stock solution format for convenient use at the bench top

TINTAGEL, England - Thermo Fisher Scientific Inc., the world leader in serving science, today announced that the Maybridge Ro3 Diversity Fragment Library is now available in a new prepared format, with each compound pre-dissolved as a DMSO solution.

A gold standard for lead generation, the Maybridge Ro3 Diversity Fragment Library contains a broad range of 1,500 compounds, many of which are small-molecule pharmacophores available only from Maybridge. Manufactured and selected specifically to meet "Rule of Three" requirements, these fragments are an ideal first step in pharmaceutical lead development.

The new ready-to-use format offers complete user convenience, saving time on sample and stock solution preparation. Available in three 500-compound sets, each compound in the library is pre-solubilised as a 1ml 10mM solution, providing 10µMol of 95 percent purity pharmacophore dissolved in analytical grade DMSO. The libraries are also available at higher concentrations upon request to meet specific customer needs.

The Maybridge Ro3 Diversity Fragment Library is provided in standard, automation-compatible, matrix tube and latch-rack formats and is also available pre-packaged to fit any standard microplate footprint, with cap mat seals for automated, high-throughput applications. Each compound has a Tanimoto similarity index of 0.66, allowing for superb structural diversity across the library. The library contains a large number of compound fragments that are linker friendly, enabling them to be incorporated into larger drug molecule backbones.

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About Maybridge

Maybridge, part of Thermo Fisher Scientific, is well known for providing highly innovative drug-like molecules and screening compounds for drug discovery and development. With products available for both lab and development scale, they specialize in producing new heterocyclic and phenyl ring-based chemical building blocks, including a unique and expanding range of reactive intermediates. For more information about Maybridge brand products visit or call +44 18 40 77 05 67.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit


Media Contact Information:

Name: Sarah Perceval, Alto Marketing

Phone: +44 (0)1489 557672

Email: [email protected]

Secondary Contact Information:

Simon Pearce, Thermo Fisher Scientific

Tel: +44 (0)1840 772077

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