Fluorescence Reader evaluates protein.

Press Release Summary:

A²(TM) MicroArray fluorescence-based CCD microplate reader provides automatic quantitation of protein analytes on A² MicroArray Plate. Software aligns grid around each spot on A² MicroArray Plate and measures fluorescent intensity, which can be correlated to analyte concentration. A² Reader utilizes CCD camera technology to image one well at a time and up to 2 fluorescent wavelengths per scan. It can read plate and process data in less than 5 min.

Original Press Release:

New A2(TM) MicroArray Fluorescence Reader for High-Throughput Protein Evaluation

Fullerton, California. March, 2003 - Beckman Coulter, Inc. introduces a new fluorescence-based CCD microplate reader for the automatic quantitation of hundreds of protein analytes on the A² MicroArray Plate. The A² MicroArray Reader has been specially designed to work with the new A² MicroArray System to quantitate multiplexed immunoassays. Part of the ProteomeLab™ family of products, this protein microarray system has the potential to allow customers to detect and quantitate protein-protein interactions, protein immunoassays, DNA-protein interactions, enzymatic reactions and other protein assays. The new A² MicroArray platform overcomes many of the limitations associated with other microarray systems that involve complicated image processing manipulations. These steps can compromise accuracy and severely limit throughput. In addition, the A² Reader can read a plate and process the microarray data in less than five minutes, compared to as much as an hour for other microarray systems. Built-in, easy to use, A² Reader software quickly and precisely aligns a grid around each of the spots on the A² MicroArray Plate and measures the fluorescent intensity, which can then be correlated to analyte concentration. The A² Reader utilizes CCD camera technology to image one well at a time and up to two fluorescent wavelengths per scan. The A² Reader takes up minimal lab space, with a footprint that is about the size of a laptop computer. It can also be integrated with the Biomek' automated liquid handling platforms for complete automation of the assay. "The reader is a key element of any assay, and often represents a process bottleneck." explains Brendan Yee, Strategic Marketing Manager for Beckman Coulter. "With this entirely new approach of creating an array within a microtiter well, we can automate the sample preparation process as well as the detection and measurement of the analytes, with little or no manual intervention." ProteomeLab is a new family of proteomic tools for cellular identification and protein isolation, fractionation, characterization and evaluation. These tools can ultimately be used to identify markers for the development of disease diagnostics and therapeutic targets. Beckman Coulter, Inc. is a leading manufacturer of instrument systems. chemistries and supplies that simplify and automate laboratory processes. At the forefront of medical discovery, in clinical research and through the often life-saving process of clinical diagnostics, Beckman Coulter's 200,000 installed systems provide essential biomedical intelligence to enhance health care around the world. The company, based in Fullerton, California, reported 2002 annual sales of $2.06 billion with 62 percent of this amount generated by recurring revenue from supplies, test kits and services. For more information, access the Beckman Coulter World Wide Web Information Service at www.beckmancoulter.com or call (800) 742-2345 (U.S.). Fax (800) 643-4366 (U.S.). From outside the U.S. call (714) 871-4848, or Fax (714) 773-6611.

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