Bosch Meets Pharmaceutical Demand for Flexibility
GKF 702 and GKF 2500 capsule filling machines
· Maximum flexibility, modularity and precise dosing
· GKF 702: Versatile platform is a future-proof investment
· GKF 2500: Micro dosing with high performance and maximum precision
Bosch Packaging Technology demonstrates its expertise in capsule filling machines with the GKF 702 for small and medium-sized batches, along with the high-performance GKF 2500 equipped with a micro dosing station.
"The GKF 702 offers the same flexibility and user-friendly operation as the GKF 701, which has been successful on the market for the past nine years," explained Product Manager Melanie Beck. The new design offers improved ergonomics and accessibility. Meeting the growing needs in today's pharmaceutical industry for flexibility, the unit can be used in the lab for extremely small batches. Parameters required in future production operations can be comprehensively simulated and defined. "This makes it possible to fill very small batches for pharmaceutical or clinical purposes under realistic production conditions," Beck added.
Micro dosing of powders is used on the high-performance GKF 2500. "This machine gives customers the ability to handle micro dosing with maximum yield and precision, and minimum deviation from standards," said Beck.
Flexible solutions for planning reliability and improved availability
The extremely flexible GKF 702 capsule filling machine is suitable for all standard filling techniques. Recently, the portfolio has been enhanced to include dosator technology. For laboratory applications, Bosch developed the so-called "mini-bowl" for small product batches ranging from 100 to 300 milliliters to ensure a higher powder yield. This provides a costeffective filling solution that is ideal for expensive powders or limited availability during the development phase.
The pellet station enables gentle and precise filling of pellets and can be used in conjunction with other stations for combination products. The liquid station is suitable for thixotropic and hydrophilic liquids that can also be temperature controlled during the filling process. Powder filling is conducted with the proven filling/stamping station. The "slide-gate" system featured on the 1400/2500 series machines is now available for the GKF 702 filling station. This significantly increases batch yield and enables filling of free-flowing granules and pellets. The slide-gate system also increases product flexibility since powder and pellets can be filled on the same station.
The GKF 702 is a future-proof machine. Compatibility with new filling stations is one of the key features of the machine design. For example, the GKF 2500 micro dosing unit is also available for the GKF 702.
Micro dosing on the GKF 2500
Micro dosing refers to filling quantities of less than 30 milligrams. Precise filling of minuscule doses without agglomeration is essential for highly active inhalation products that require exact dosages. This is why Bosch developed a dosing wheel designed for use with highly active inhalation products with quantities ranging from two to 30 milligrams. Micro dosing is suited for application on, for instance, the high-performance machine GKF 2500.
The modular, flexible filling station can also be used for hard-to-fill products. Adjustments can be made as necessary during the filling process without removing the filling roller. This saves time and reduces waste. "The GKF 2500 meets all requirements for pharmaceutical production and offers manufacturers a gentle filling process with need-based application," said Melanie Beck. Designed to meet future needs, the filling station can be easily assembled and disassembled. The small number of format parts makes machine changeover for a new product faster and easier. The GKF 2500 is suitable for flexible processing of a wider range of products with a higher yield.
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The Bosch division Packaging Technology, based in Waiblingen (Germany), is one of the leading suppliers in the field of processing and packaging technology. In more than 15 countries worldwide it develops and produces complete solutions for the pharmaceutical, food and confectionery industries. The comprehensive service portfolio completes the package. The worldwide sales and service network offers local contacts. More information at www.boschpackaging.com
The Bosch Group is a leading global supplier of technology and services. In the areas of automotive and industrial technology, consumer goods, and building technology, more than 300,000 associates generated sales of 51.5 billion euros in fiscal 2011. The Bosch Group comprises Robert Bosch GmbH and its roughly 350 subsidiaries and regional companies in some 60 countries. If its sales and service partners are included, then Bosch is represented in roughly 150 countries. This worldwide development, manufacturing, and sales network is the foundation for further growth. Bosch spent some 4.2 billion euros for research and development in 2011, and applied for over 4,100 patents worldwide. With all its products and services, Bosch enhances the quality of life by providing solutions which are both innovative and beneficial.
The company was set up in Stuttgart in 1886 by Robert Bosch (1861-1942) as "Workshop for Precision Mechanics and Electrical Engineering." The special ownership structure of Robert Bosch GmbH guarantees the entrepreneurial freedom of the Bosch Group, making it possible for the company to plan over the long term and to undertake significant up-front investments in the safeguarding of its future. Ninety-two percent of the share capital of Robert Bosch GmbH is held by Robert Bosch Stiftung GmbH, a charitable foundation. The majority of voting rights are held by Robert Bosch Industrietreuhand KG, an industrial trust. The entrepreneurial ownership functions are carried out by the trust. The remaining shares are held by the Bosch family and by Robert Bosch GmbH.
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Robert Bosch GmbH
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Brand Management, and Sustainability
Senior Vice President: Uta-Micaela Dürig