Benchtop LC-MS System suits compound screening and ID jobs.

Press Release Summary:

Leveraging mass analyzer technology from LTQ Orbitrap platform, Exactive can be used in analytical laboratories with routine toxicology, environmental, and drug development workflows. It delivers resolutions up to 100,000 and offers single scan mass accuracy in positive and negative modes. In addition to screening and confirming co-eluting compounds in complex matrices in one experiment, system is capable of screening isobaric compounds that differ by only a few milli-mass units.

Original Press Release:

Thermo Fisher Scientific Introduces Exactive: a New Benchtop LC-MS System for Compound Screening and Identification

Powered by Orbitrap technology

San Jose, CA (May 29 2008) - Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, today announced that it will launch the Thermo Scientific Exactive, a new benchtop LC-MS system designed for compound screening and identification applications, at ASMS 2008. Exactive leverages proven mass analyzer technology from the LTQ Orbitrap platform, the recognized standard for accurate mass and high resolution measurement, to provide precise and confident information. It is fast, easy-to-use and cost effective to operate, making it an ideal instrument for non-experts in routine analytical laboratories.

"Orbitrap technology has been an important driver of LC-MS growth in the world of biology," noted Ian Jardine, vice president of global research and development at Thermo Fisher Scientific. "We asked ourselves what we could do to fully realize the potential of this technology, to make it even more accessible to users with routine toxicology, environmental and drug development workflows. The result is an instrument that we consider a real breakthrough, that can be applied to a great number of challenging new applications."

The Thermo Scientific Exactive LC-MS streamlines many of the technical steps that normally require specialized set up and operation. An intuitive software interface makes the system easy-to-use in both expert and "walk-up" mode, while ensuring precise mass identification of target compounds over a wide concentration range.

While simple to operate, Exactive sets new standards for LC-MS performance, at resolutions of up to 100,000. When combined with excellent single scan mass accuracy in positive and negative modes, Exactive becomes an ideal system for common screening and high-throughput applications. "Mass accuracy plays a critical role in reducing analysis times and increasing confidence even in routine measurements," notes Dr. Jardine. "Co-eluting compounds in complex matrices can be screened and confirmed in a single experiment simply by reanalyzing data at a higher resolution. For screening of isobaric compounds such as pesticides that differ by only a few milli-mass units, this accurate mass capability will be of enormous value."

For more information on the Thermo Scientific Exactive LC-MS system, as well as other Thermo Scientific products, please visit the Thermo Scientific booth 41 at the 56th ASMS Conference on Mass Spectrometry and Allied Topics, in Denver, June 1-5. Alternatively, call +1 800-532-4752, email or visit

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving science.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. With annual revenues of $10 billion, we have more than 30,000 employees and serve over 350,000 customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as environmental and industrial process control settings. Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. Thermo Scientific offers customers a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. Fisher Scientific provides a complete portfolio of laboratory equipment, chemicals, supplies and services used in healthcare, scientific research, safety and education. Together, we offer the most convenient purchasing options to customers and continuously advance our technologies to accelerate the pace of scientific discovery, enhance value for customers and fuel growth for shareholders and employees alike. Visit

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