Dynamic Light Scattering System hastens protein characterization.
Press Release Summary:
October 3, 2012 - Zetasizer Nano ZSP enables high-sensitivity measurement of zeta potential for accelerated measurement of electrophoretic mobility of proteinsÂ and calculation of protein charge key parameters. Requiring 20 ÂµL of sample, instrument measures zeta potential at concentrations down to 1 mg/mL. Measurement quality is optimized via software that combines size and zeta potential measurements; mobility measurements performed in groups of sub-runs; and automatic measurement settings optimization.
Original Press Release
Malvern's New Zetasizer Nano ZSP Delivers Fast, High Sensitivity Protein Characterization for Multiple Applications
Press release date: September 27, 2012
Key to achieving superior protein mobility measurements are a highly sensitive measurement system, the ability to protect the sample from aggregation, and flexible software that presents data in an immediately usable format. The Zetasizer Nano ZSP has the count rate sensitivity needed to easily measure weakly scattering samples such as proteins, and the instrument’s protein mobility measurement process is designed to maximize measurement quality using three specific features. Firstly, by combining size and zeta potential measurements the Zetasizer software can ensure that no aggregates are forming during the measurement, and warn the user is this does start to occur. Secondly, mobility measurements are performed in groups of sub-runs to allow extended periods of cooling, reducing the possibility of aggregation through heating. And thirdly, automatic optimization of measurement settings minimizes denaturation and aggregation during mobility measurements.
A suite of protein calculators has been added as part of the software developments that accompany the launch of the Zetasizer Nano ZSP, which are included with the instrument as standard. These include a dynamic DLS Debye Plot which allows calculation of the DLS interaction parameter, especially useful in protein formulation for biological therapeutics. There is also the ability to calculate protein charge from protein mobility, F(ka) from the Henry equation, interparticle distance, and thermodynamic diameter (virial radius).
Find out more at www.malvern.com/nano-zsp
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About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical identification. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.
Malvern’s measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com
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