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Filling and Closing Machine includes capping station.

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Filling and Closing Machine includes capping station.
Filling and Closing Machine includes capping station.
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May 19, 2014 - Depending on output and container, FXS Combi, with 2 or 5 positions, processes pre-sterilized nested syringes, vials, and cartridges. Integrated capping station enables capping of vials and cartridges directly after stopper insertion, ensuring pharmaceutical safety. Operating with up to 6 dosing heads, machine is suitable for all common filling technologies, such as peristaltic or rotary slide valve piston pumps as well as single-use filling technology PreVAS.

Market Launch: New Filling and Closing Machine FXS Combi from Bosch

Bosch Packaging Technology NA
8700 Wyoming Ave. N.
Minneapolis, MN, 55445

Press release date: May 1, 2014

Flexible solution for syringes, vials and cartridges in combination
Filling and closing of pre-sterilized nested syringes, vials and cartridges
Integrated capping station saves space and ensures maximum pharmaceutical safety
Flexible integration into fully automated line concepts

Duesseldorf, Germany — At Interpack 2014, Bosch Packaging Technology, a leading supplier of process and packaging technology, presents the new filling and closing machine FXS Combi for the first time. Depending on output and container, the machine with two or five positions processes pre-sterilized nested syringes, vials and cartridges. The FXS Combi is the first filling and closing machine of this kind with an integrated capping station for vials and cartridges. It can be easily integrated into line concepts, allowing for significant space savings. The FXS Combi is suited for low and medium output rates.

Flexibility for various packaging types
The FXS Combi is an advancement of the proven FXS platform and features flexible and quickly exchangeable format parts for diverse packaging types. “To fulfil our customer’s demands for higher flexibility, a more compact footprint and extended fields of application, we transferred the successful FXS concept to further, pre-sterilized packaging types,” Klaus Ullherr, product manager at Bosch Packaging Technology explained.

“During the development of the FXS Combi, we benefitted from our many years of experience in the safe and reliable processing of syringes, vials and cartridges,” Ullherr said. The FXS Combi is the first filling and closing machine of this kind with an integrated capping station. In the consistent monobloc solution, the capping of vials and cartridges takes place directly after the stopper insertion. This ensures highest pharmaceutical safety, as the container is immediately and safely closed after filling.

Integration into fully automated line concepts
The FXS Combi operates with a combi filling station with up to six dosing heads. This makes the machine suitable for all common filling technologies, such as peristaltic or rotary slide valve piston pumps as well as the single-use filling technology PreVAS. A combination with different barrier systems is also possible; the FXS Combi is suited for both Restricted Access Barrier Systems (RABS) and isolators. By combining the new filling and closing machine with the proven upstream ATO tub opener and ABO bag opener from Bosch, it can be integrated into fully automated line concepts.

The filling and closing machine is also suited for processing vials for lyophilization, which ensures a longer life span of the pharmaceuticals. Especially high-priced pharmaceutical products and packaging types require a high product yield. Filling on a checkweigher during the start-up and run-empty process makes almost 100 percent of the pharmaceutical liquids usable for filling. Filling weights are checked via statistical in-process control (IPC). “Together with our single-use filling system PreVAS, the FXS Combi contributes to a more efficient and faster development of new medications, for instance for the treatment of cancer,” Ullherr said.

Bosch's technologies are on display at Interpack 2014, Duesseldorf, Germany from May 8 to 14 in hall 6, booth A31 – C58.

Klaus Ullherr: phone: +49 7951 402-517

Based in Waiblingen near Stuttgart, Germany, and employing 5,600 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact.

Additional information is available online at

The Bosch Group is a leading global supplier of technology and services. In 2013, its roughly 281,000 associates generated sales of 46.1 billion euros. (NB: Due to a change in accounting policies, the 2013 figures can only be compared to a limited extent with the 2012 figures). Its operations are divided into four business sectors: Automotive Technology, Industrial Technology, Consumer Goods, and Energy and Building Technology. The Bosch Group comprises Robert Bosch GmbH and its roughly 360 subsidiaries and regional companies in some 50 countries. If its sales and service partners are included, then Bosch is represented in roughly 150 countries. This worldwide development, manufacturing, and sales network is the foundation for further growth. In 2013, the Bosch Group invested some 4.5 billion euros in research and development and applied for some 5,000 patents. This is an average of 20 patents per day. The Bosch Group’s products and services are designed to fascinate, and to improve the quality of life by providing solutions which are both innovative and beneficial. In this way, the company offers technology worldwide that is “Invented for life.”

Further information is available online at  and,
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