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Waters Expands UNIFI Solutions with Three New Applications: Glycans, Forensic Toxicology and Natural Products

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Waters Corporation
34 Maple St.
Milford, MA, 01757
USA



Press release date: January 29, 2014

Waters Now Offers Eight UNIFI-Based Solutions based on the Premier Multi-User, Server-Based Technology for Management of Analytical LC, LC/MS, and LC/MS/MS Data

MILFORD, Mass. -- Waters Corporation (NYSE: WAT) today announced three new UNIFI( )Scientific Information System solutions: the Waters( )Glycan Application Solution with UNIFI, Forensic Toxicology Screening Application Solution with UNIFI, and the Natural Products Application Solution with UNIFI. Each new application features a proprietary comprehensive library of relevant molecules.

"Not only does our most recent release of the Waters UNIFI Scientific Information System demonstrate improved software performance such as customizable workflows capabilities and multi-user workgroup server-based connectivity, but new users will benefit from access to powerful library databases for their specific applications," said Dr. Rohit Khanna, Vice President of Informatics and Worldwide Marketing for Waters. "These application specific libraries enable our customers to optimize application methods for improved robustness, performance, and processing speed for the quantification of known chemical compounds and the identification of new species."

The Glycan Application Solution withUNIFI(TM)( ) features an extensive N-glycan Glucose Unit (GU) reference database that was developed in collaboration with the National Institute for Bioprocessing Research and Training (NIBRT). The Waters Glycan GU Library, used along with Waters' robust and bioseparations-focused analytical technologies to characterize glycosylation, enables biopharmaceutical laboratories to deliver well-characterized biotherapeutics from discovery through development and QC operations. The solution facilitates routine assignment of N-linked glycan structures, and enables profiling of released glycans for individual sample analysis and expedites multi-batch comparability studies for either innovator biotherapeutics or biosimilars. The system solution consists of the ACQUITY UltraPerformance LC() (UPLC()) H-Class System, an ACQUITY UPLC() Fluorescence (FLR) Detector, the Xevo() G2-S QTof Mass Spectrometer, Waters' application-tested bioseparation column chemistries, and analytical glycan standards used for system familiarization training, GU-retention time calibration and routine glycan system function checks. This new Glycan Application Solution with UNIFI complements intact protein analysis and peptide mapping applications that are also available within the Biopharmaceutical Platform Solution with UNIFI.

Waters Forensic Toxicology Screening Application Solution with UNIFI(TM)( ) was devised with direct input from forensic scientists within active forensic toxicology laboratories. A complete toxicology solution, the platform integrates chromatography method, mass spec and software to enable a robust, end-to-end solution that requires minimal or no method development. The software includes a comprehensive database of compounds of toxicological interest which can easily be extended to address 'unknown' analytes that may be germane to the evidence. Furthermore, UNIFI reporting capabilities present forensic sample analysis results in a meaningful and relevant manner to improve the forensic laboratory workflow, output and turnaround time. Lastly, the UNIFI software security is well tailored to meet the stringent chain-of-custody standards of forensic toxicology laboratories. In addition to the UNIFI software platform, the application solution consists of the ACQUITY UltraPerformance LC() (UPLC()) I-Class, the Xevo() G2-S QTof mass spectrometer and Waters' application-tested HSS column chemistries.

Also built upon the Waters Screening Platform Solution, the Natural Products Application Solution with UNIFI(TM) enables laboratories to readily move from sample extract to product knowledge using a sensitive and accurate-mass analytical platform integrated with fit-for-purpose workflows and reporting. The solution features a "Traditional Medicines" library including all the herbs detailed in the 2010 Chinese Pharmacopeia. The integration of data acquisition and processing with the Traditional Medicine library provides a simple, efficient process to effectively facilitate the identification and comparison of chemical ingredients from complex natural product samples. This greatly improves productivity and reduces the demands for operator's technical expertise level. The application solution consists of the ACQUITY UltraPerformance LC() (UPLC()) I-Class System, an ACQUITY UPLC TUV Detector, the Xevo() G2-S QTof mass spectrometer, Waters' application-tested High Strength Silica (HSS) column chemistries and application-specific analytical standards.

These three new application solutions can be deployed and configured to meet the needs and offer unique UNIFI capabilities to multi-user, server-based workgroups for the capture, storage, and management of analytical LC, LC/MS, and LC/MS/MS data. Additionally, UNIFI manages and stores exponentially larger dataset files with improved robustness, performance and processing speed which is a major step forward for advancing UNIFI as an enterprise-wide Scientific Information System. From data acquisition to advanced interpretation and reporting, UNIFI comprehensively streamlines scientific workflow.

In addition to the UNIFI three application solutions mentioned, Waters offers the following five system solutions as well:

The existingBiopharmaceutical Platform Solution with UNIFI(TM) platform, enabling the deployment of high-resolution UPLC or UPLC/QTof-MS analytics across the innovator biotherapeutic or biosimilar development process.

Regulated Bioanalysis Platform Solution with UNIFI(TM) is an LC/MS/MS system for drug metabolism and pharmacokinetic (DMPK) organizations and CROs that combines the latest in sample preparation, UPLC and chemistries, and tandem quadrupole mass spectrometry.

Screening Platform Solution with UNIFI(TM) is the first and only comprehensive screening solution to target, identify, quantify and review based on a streamlined analytical workflow that enables more accurate results across a variety of applications. The holistically designed Platform Solution consists of the ACQUITY UPLC I-Class, the Xevo G2-S QTof mass spectrometer, Waters Analytical Standards & Reagents and Waters Chemistries.

Pesticide Screening Application Solution with UNIFI(TM) delivers the ease-of-use, sensitivity, stability, reproducibility, and throughput scientists need to successfully and profitably perform pesticide residue screening in a manner compliant with regulatory requirements today and in the future.

Metabolite Identification Application Solution with UNIFI(TM) is the world's most comprehensive metabolite identification system assisting the DMPK scientist in identifying and characterizing metabolites in both discovery and development environments. Chemically intelligent yet flexible workflows are at the core of UNIFI's design. The workflow approach integrates both quantitative and qualitative datasets and workflows into a single analysis.

With its comprehensive portfolio of chromatography, mass spectrometry, informatics, and chemistry technologies, Waters is uniquely positioned to develop end-to-end solutions that make otherwise challenging applications routine.

About Waters Corporation (www.waters.com)
For over 50 years, Waters Corporation (NYSE:WAT) has created business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.

With revenue of $1.90 billion in 2013, Waters is driving scientific discovery and operational excellence for customers worldwide.

Waters, ACQUITY UPLC, UPLC, UltraPerformance LC, XSelect, Xevo, UNIFI, GlycoWorks, AutoBlend Plus, Stepwave, Q-Tof and CSH are trademarks of Waters Corporation.

CONTACT:
Jeff Tarmy
Waters Corporation
+1 508-482-2268
jeff_tarmy@waters.com

Web Site: http://www.waters.com
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