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Specialists from Malvern Instruments Present New Ways of Accelerating Development of DPI Formulations

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Specialists from Malvern Instruments Present New Ways of Accelerating Development of DPI Formulations
Specialists from Malvern Instruments Present New Ways of Accelerating Development of DPI Formulations
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Malvern Instruments Ltd
Enigma Business Park
Malvern Worcestershire, WR14 1XZ
United Kingdom



Press release date: April 16, 2014

Malvern, UK: At the Respiratory Drug Delivery (RDD) 2014, specialists from Malvern Instruments will present a new approach to help accelerate the development of dry powder inhalation (DPI) formulations. Malvern will also be exhibiting the Morphologi G3-ID particle characterization system at the event which takes place on 4 - 8 May, in Farjado, Puerto Rico. For more information, visit http://bit.ly/RDDMalvern.

The presentation from Malvern is entitled 'Combining Morphologically Directed Raman Spectroscopy with Next Generation Impactor (NGI) Analysis to improve the understanding of particle properties of Dry Powder Inhalation Formulations.' It presents data showing how the use of Malvern's Morphologi G3-ID particle characterization system in conjunction with NGI can help researchers develop thorough understanding of the relationship between the physical attributes of an excipient with the dispersion of active pharmaceutical ingredient from a DPI, allowing formulators to engineer a formulation to achieve a product's target performance profile. This new approach may also aid generic pharmaceutical companies with de-formulation - understanding and matching the operation of innovator products - and in determining bio-equivalence.

In the presented work the Morphologi G3-ID, which combines automated imaging capabilities with Raman spectroscopy for chemical identification of individual particles, was used to gather component-specific size and shape information for particles in a commercial DPI. Doses from a DPI were size fractionated using the NGI, which is a cascade impactor widely employed for the testing of products administered by inhalation. Individual particles delivered to the different stages of the NGI were then chemically identified using the Morphologi G3-ID to generate component-specific particle size distributions. Multi-component agglomerates were also analyzed to understand the dynamics of dose dispersion, which is a critical aspect of drug delivery and has an impact on a formulation's bioavailability.

The Morphologi G3-ID from Malvern combines static image analysis with Raman spectroscopy to determine component-specific particle properties of mixtures and blends, including those used in pharmaceutical products such as tablets, nasal sprays and asthma inhalers. Powerful but easy-to-use, the Morphologi G3-ID provides size, shape and chemical analysis information for particles in the size range 0.5 m - 1000 m for a variety of sample types, including dry powders, liquids and creams.

To find out more about Malvern's Morphologi G3-ID, visit http://www.malvern.com/morphologi-g3-id

For details on the Respiratory Drug Delivery conference, visit http://bit.ly/RDDMalvern

Malvern, Malvern Instruments, and Morphologi are registered trademarks of Malvern Instruments Ltd

About Malvern Instruments
Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern's materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.

Our products reflect Malvern's drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.

Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com

Facebook: MalvernInstruments
Blog: www.materials-talks.com
Youtube: malverninstruments
Linked-In: malvern-instruments
Twitter: malvern_news
Google +: https://plus.google.com/+malvern

USA contact:
Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403
marisa.fraser@malvern.com

Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456
Fax: +44 (0) 1684 892789
salesinfo@malvern.com
www.malvern.com
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