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Genedata Announces Collaboration with AstraZeneca on the Analysis of Compound Combination Experiments

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Genedata AG
Maulbeerstrasse 46
Basel, CH-4016
Switzerland



Press release date: December 3, 2013

Genedata Screener® serves as the data analysis platform for high-throughput compound combination experiments in oncology and infectious diseases 
 
Basel, Switzerland – Genedata, a leading provider of advanced software solutions for drug discovery and life science research, today announced its successful collaboration with AstraZeneca on data analysis for compound combination experiments. Drug combination studies, which are increasingly used in pre-clinical research, produce large volumes of data with upwards to 200 combinations per experiment. Genedata Screener, which has been proven to work as an easy and efficient platform for analyzing compound screening, has been advanced through the AstraZeneca collaboration as Genedata Screener now automates and standardizes the analysis of compound combination experiments.

"With Genedata, we are able to extract the highest value possible from our compound combination experiments," noted Dr. Eric Tang, associate principle scientist at AstraZeneca. "Typically, compound combination experiments compare 50 or more compounds across a number of cell lines in a single study, resulting in the analysis of hundreds of 384/1536 well plates. Genedata Screener can handle these large data sets and enable us to generate and compare results for the same compound combinations in different cell lines, and review alternative analysis for the same data sets. Moreover, Screener helps standardize data analysis giving us more quality time to conduct detailed analysis," continued Dr. Tang.

From Raw Data to Synergy Scores in Minutes
Combination therapies - the simultaneous use of a variety of drugs to treat a range of diseases from infections to cancer - have gained importance as a cure. And, compound combination experiments are a resurging trend in lead optimization and target validation. Data sets from these experiments tend to be large, as the number of measurements scales exponentially with the number of compounds to be compared. Genedata Screener effectively addresses the data analysis challenges of these large data sets by enabling researchers to:
Go from raw data to results in less than 30 minutes, also for large studies
Eliminate time-consuming manual data processing
Interactively inspect raw data and check the quality of normalized values
Review in-depth  intermediate and final results using combination-specific displays such as concentration matrices and isobolograms
Automatically fit both mono-therapeutic and combination dose-response curves for quick and robust results
Display, quantify and compare measured and expected combination effects for different interaction models such as Loewe, Highest Single Agent, or Bliss
Access all processing steps throughout the workflow

"We see a huge demand for software that efficiently analyzes compound combination experiments in novel drug discovery," said Dr. Othmar Pfannes, CEO of Genedata. "Our successful collaboration with AstraZeneca, a leader in combination therapies, helps us to further advance Genedata Screener as the platform of choice for the efficient analysis of compound combination experiments."

About Genedata
Genedata transforms data into intelligence with a portfolio of advanced software solutions, which make research data accessible and understandable and research processes more efficient. These solutions are used worldwide by leading pharmaceutical, industrial, and agricultural biotechnology companies as well as academic research organizations. Genedata innovations enable scientific discovery that fights disease and improves health and quality of life worldwide. Founded in 1997, Genedata is headquartered in Switzerland, and has offices in Germany, Japan, and the US.

www.genedata.com 

Contacts
Allison Kurz
Genedata
Marketing & Communications
Phone: +41-61-511-8459
communications@genedata.com

All product and service names mentioned are the trademarks of their respective companies.

Genedata AG 
Margarethenstrasse 38
4053 Basel, Switzerland 
Tel. +41 61 511 8400 
Fax +41 61 511 8484

Genedata Inc. 
750 Marrett Road
One Cranberry Hill
Suite 403
Lexington, MA 02421 
Tel. +1 781 357 4755 
Fax +1 781 357 4770

Genedata Inc. 
109 Stevenson Street
4th Floor
San Francisco, CA 94105 
Tel. +1 877 436 3872 
Fax +1 415 970 6631

Genedata GmbH 
Lena-Christ-Strasse 50
82152 Martinsried, Germany 
Tel. +49 89 4581 9010 
Fax +49 89 4581 9015

Genedata KK - 1-7-11
Higashi-Gotanda
Shinagawa-Ku
Tokyo 141-0022, Japan 
Tel. +81 3 6721 7261 
Fax +81 3 6721 7262
www.genedata.com
communications@genedata.com

Genedata | Margarethenstrasse 38 | Basel | 4053 | Switzerland

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