Waters Makes It Possible with New Mass Spectrometry Systems, Exciting Collaborations at Pittcon 2007


Waters Showcasing First-Of-Its-Kind High Definition Mass Spectrometry System and Important Partnerships

CHICAGO, Feb. 26 // -- Continuing to build momentum on the innovative successes of 2006, and to complement the launch of its new branding campaign, The Science of What's Possible(TM), Waters Corporation (NYSE:WAT) is showcasing a host of impressive new products and sharing news of its exciting collaborations at the 58th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, February 25 -- March 2.

Highlighting Waters product news is the Pittcon premiere of a first-of- its-kind mass spectrometry system, the Synapt(TM) High Definition MS(TM) (HDMS) System, and a benchtop, ultra-compact, tandem-quadrupole, atmospheric pressure ionization mass detector called the Waters TQ Detector used in conjunction with Waters(R) ACQUITY(TM) UPLC(R) System.

Making Waves in Mass Spectrometry

The Synapt HDMS(TM) system is the first mass spectrometer of its kind to employ new ion mobility technology and software to enable the analysis of sample ions differentiated by size, charge, shape and mass. This additional dimension of separations fidelity leads to improved specificity and sample definition, allowing scientists to extract more information about their samples, including the detection of previously unseen constituents.

A key feature of this new system is the patented Waters Triwave(TM) technology, a unique method for combining highly efficient ion mobility based measurement and separations with high performance quadrupole time-of-flight mass spectrometry. Operational control and data acquisition and processing are performed through Waters MassLynx(TM) Software.

Waters is also showcasing its new tandem UPLC/MS/MS system solution, the ACQUITY TQD, allowing chromatographers to easily and confidently acquire UPLC/MS/MS data in routine analytical and open access settings. This UPLC/MS/MS system features the new Waters TQD -- a benchtop, ultra-compact, tandem-quadrupole, atmospheric pressure ionization (API) mass detector designed for routine UPLC/MS/MS analyses. With first-of-its-kind IntelliStart(TM) technology to integrate the internal calibration fluidics and advanced diagnostics software, the system automatically tunes and calibrates the ACQUITY TQD System and conducts full UPLC/MS/MS performance checks.

Making a Difference in People's Lives

Waters arrives at this year's Pittcon as a new, proud partner to a number of the world's most dedicated healthcare companies, renowned academic research facilities, and esteemed government agencies.

Dedicated Healthcare Companies

Waters and Advion Biosciences, Inc., of Ithaca, NY, also recently integrated a number of their products to offer life scientists enhanced research capabilities. The Advion(TM) TriVersa(TM) NanoMate chip-based infusion technology was combined with Waters Synapt HDMS System to help researchers maximize the amount of information they can extract from their complex samples by combining the ease-of-use and reproducibility of Advion's nanoelectrospray chip-based sample introduction technology with the additional dimension of ion mobility-based separation provided by the Synapt HDMS System. This technology is one of the most advanced of its kind, and it supports the life-saving research of the world's top pharmaceutical companies, government life science research agencies, and universities.

Renowned Academic Research Facilities

At the start of 2007, two world-renowned research institutions, the Max Planck Institute and Oxford University, added the Waters Synapt HDMS System to their research technologies. Max Planck's Department of Cellular Biochemistry is now employing the Synapt HDMS System to study the role of proteins in causing brain-wasting diseases, including Huntington's. Similarly, Oxford is using the Synapt HDMS System to study multi-component protein complexes that can help answer questions like how to starve cancerous tumors of oxygen and how to oxygenate and, some day, restore heart tissue damaged by various forms of heart disease.

In late 2006, London's Imperial College unveiled a new state-of-the-art NMR facility incorporating the mass spectrometry-based Waters Laboratory of Molecular Spectroscopy. The collaboration and new facility allows researchers at Waters and Imperial College to address fundamental medicinal-biology problems, which are helping pave the way for a better understanding of the underlying causes of disease and the effect of lifestyle and diet on health. The work being done at this library is helping to provide the tools necessary to make significant steps toward the goal of personalized medicine.

Esteemed Government Organizations

This month, Waters entered into a Cooperative Research and Development Agreement (CRADA) with the U.S. Environmental Protection Agency's (EPA) National Exposure Research Laboratory to develop trace level analytical methods for detecting levels of perfluorinated compounds (PFCs) in soil and water. Waters and EPA scientists will develop analytical methods employing liquid chromatography and mass spectrometry to measure PFCs at very low concentrations in water and soil. CRADA will then focus on providing answers as to the exposure risks of these pollutants to humans.

In the summer of 2006, Waters announced collaborations with the China Municipal Center for Disease Prevention and Control (China CDC), Beijing Municipal Center for Disease Prevention and Control (BJCDC) and The Research Center for Eco-Environmental Sciences (RCEES) of the Chinese Academy of Sciences to provide technology and expertise for food safety analysis and environmental regulatory compliance. This joint collaboration with China's premier food safety and environmental centers signifies a strong vote of confidence in Waters and its commitment to address China's rapidly increasing food safety and environmental challenges, particularly as the country moves toward hosting the 2008 Olympics.

Our Pittcon Offerings

Waters Corporation is consolidating its instrumentation, chemistry, and informatics products into Booth 3641.

News Conference

Waters' Pittcon 2007 News Conference, featuring Mary Ellen Goffredo, Senior Director, Systems Product Marketing, Waters Corporation will be held Monday, February 26th, from 8:30am-9:30am at McCormick Place South, Room S105A.

Scientific Presentations

Waters will host a variety of oral/poster sessions and symposia that will provide the ideal environment in which to share knowledge, expertise and the latest application approaches to solving analytical challenges using the most advanced mass spectrometry technology.

Morning and afternoon sessions will include a number of presentations and 27 educational seminars by leading scientists on the topics of drug discovery, metabolite identification, food safety, environmental health, and protein characterization.

Presentation topics will include:
o Simplifying the Purification Process
o The Identification of New Novel BioMarkers of Disease and Toxicity
o Applications of a New Amino Acid Analysis Method
o Identification of Impurities Using Liquid Chromatography Hyphenated
with Tandem Mass Spectrometry
o Screening of Drinking Water for Deleterious Organics Using LCMS and
Automatic Library Searching
o The Rapid Analysis of Anthocyanidins in Berries
o Determination of Priority Pesticide Residues in Baby Food
o Solving Real Metabolism Problems by Using Small Particles, High
Temperatures and Long Columns to Produce an Ultra High Resolution
LC/MS System

Waters will also host a special Food Safety symposium on Thursday, March 1, which will include a cross-section of representatives from industry, government and food suppliers. The panel will discuss the use of analytical technologies for solving food safety issues in an increasingly complex and vigilant global marketplace.

For more information on Waters' conference offerings, please visit: waters.com/pittcon

About Waters Corporation (www.waters.com)

Waters Corporation (NYSE:WAT) creates business advantage for laboratory- dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.

With revenue of $1.28 billion in 2006 and 4,500 employees, Waters is driving scientific discovery and operational excellence for customers worldwide.

Waters, ACQUITY, UPLC, ACQUITY UPLC, Synapt, High Definition MS, HDMS, Triwave, MassLynx, The Science of What's Possible and IntelliStart are trademarks of Waters Corporation. Advion, NanoMate and TriVersa are trademarks of Advion Biosciences, Inc.

Source: Waters Corporation

CONTACT: Media, Brian J. Murphy,
Corporation Communications, +1-508-482-2614, Brian_J_Murphy@waters.com, both of Waters Corporation

Web site: www.waters.com/
pittcon www.waters.com/

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