Thermo Fisher Scientific's TurboFlow Technology Reduces Matrix Effects in LC-MS/MS Analysis

SAN JOSE, CA (June 29, 2007) - Thermo Fisher Scientific Inc., the world leader in serving science, announces that the company's TurboFlow(TM) technology can assist pharmaceutical researchers to comply with U.S. Food and Drug Administration (FDA) regulatory guidelines on matrix effects, particularly for LC-MS/MS analysis. Thermo Scientific TurboFlow technology coupled with the Thermo Scientific TSQ Quantum(TM) triple quadrupole mass spectrometer and FAIMS (High-Field Asymmetric Ion Mobility Mass Spectrometry) technology provides an integrated LC-MS/MS solution.

When used with the TSQ Quantum, the system delivers fast and efficient quantitative results with the lowest ion suppression and chemical noise, resulting in highly sensitive bioanalytical methods, development of more robust methods and reduction in analysis failures. This unique solution allows scientists to reduce matrix effects during pre-clinical bioanalysis, making it easier to comply with the FDA/CDER Bioanalytical Method Validation Guidance that states: "In the case of LC-MS-MS-based procedures, appropriate steps should be taken to ensure the lack of matrix effects throughout the application of the method, especially if the nature of the matrix changes from the matrix used during method validation."

TurboFlow technology assists pharmaceutical researchers in reducing matrix effects by retaining small molecules, excluding proteins and larger materials. This enables users to directly inject biological samples into the LC-MS/MS system prior to analysis, a significant advantage in preclinical bioanalysis, where extensive sample preparation is time-consuming and costly.

For more information on the TurboFlow(TM) technology visit and for more information about the Thermo Scientific LC and MS product portfolio please visit, call +1 800-532-4752 or e-mail

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving science.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. With an annual revenue rate of more than $9 billion, we employ 30,000 people and serve over 350,000 customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as environmental and industrial process control settings. Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. Thermo Scientific offers customers a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. Fisher Scientific provides a complete portfolio of laboratory equipment, chemicals, supplies and services used in healthcare, scientific research, safety and education. Together, we offer the most convenient purchasing options to customers and continuously advance our technologies to accelerate the pace of scientific discovery, enhance value for customers and fuel growth for shareholders and employees alike. Visit

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Stephanie Kubina
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