Software targets primary cell and developmental biologists.
Press Release Summary:
AxioVision FRET (Fluorescence Resonance Energy Transfer) microscopy software v4.6 uses correction techniques or acceptor bleaches to determine FRET portion of FRET-coded color images. Allowing selection of optimal method for respective examinations, software enables measuring regions to be positioned at sites of FRET action, while activity can be observed during experiment. It also allows automatic capture of time series images and standard fluorescent photos.
Original Press Release:
For Cell and Developmental Biology: Release 4.6 of the AxioVision FRET Microscopy Software from Carl Zeiss Allows the Comprehensive and Fast Evaluation of FRET Measurements
Göttingen, December 2006. Carl Zeiss MicroImaging GmbH has now
incorporated numerous enhancements in the AxioVision FRET software
(Fluorescence Resonance Energy Transfer). It combines all current
methods of FRET measurement by using different correction techniques
or acceptor bleaches. This makes it possible to also determine the
FRET portion in FRET-coded color images. In addition, the evaluation
can already be performed online during the capture of time series
images.
The FRET method allows the determination of the energy transfer
portion between two closely adjacent protein molecules or the
measurement of the distance between two closely adjacent protein
molecules below the microscope resolution. It is used to determine
quantitative temporal and spatial information about the bonding and
interaction between proteins, lipids, enzymes, DNS and RNS.
The software enhancements will be quickly appreciated by users -
primarily cell and developmental biologists - in their daily work. For
example, AxioVision FRET 4.6 facilitates the selection of the optimal
method for the respective examinations. This means that the often very
time-consuming programming of the work routines and computations is
now a thing of the past. In addition, the measuring regions can now be
exactly positioned at the sites of the FRET action; in the past, this was
only possible with approximate exactness in the gray scale images.
Another new feature is the possibility of observing the FRET activity
during the experiment being performed.
Further benefits include the automatic capture of all required time series
images (donor, acceptor and FRET) and the extremely simple operation
via a few keys in six logical control windows. The system can also be
used for capturing standard fluorescent photos. The program
additionally contains all functions of AxioVision LE.
In combination with the motorized ZEISS Axio Imager or Axio Observer
microscopes, the AxioVision FRET software provides a convenient tool
for FRET examinations. However, it can also be used with the
motorized Axioplan 2 Imaging, Axioskop or Axiovert 200 stands. Finally,
it can also be utilized on manual fluorescence microscopes with the
appropriate filter sets.
Contact in the US:
Karin Salerno
Marketing Communications Manager
Carl Zeiss MicroImaging, Inc.
One Zeiss Drive
Thornwood, NY 10594
Phone: (914) 681-7627
Email: ksalerno@zeiss.com
PI No. I19 / US: 01/07 January 2007
Carl Zeiss MicroImaging GmbH, a company of the Carl Zeiss Group, offers
microscopy solutions and systems for research, laboratories, routine and industrial
applications, as well as spectral sensors for the analysis market. The company
develops, produces and markets instruments, software and accessories for
microscope systems and associated techniques up to and including special
solutions for process analysis. Carl Zeiss MicroImaging GmbH emerged from the
Microscopy Group as a 100% subsidiary of Carl Zeiss AG on March 01, 2006.
During fiscal year 2005/06 the Microscopy Group at Carl Zeiss generated revenues
of approximately EUR 340 million with a global workforce of about 1600. Further
information is available under http://www.zeiss.com/micro.
Carl Zeiss is a leading international group of companies operating worldwide in
the optical and opto-electronic industry. In fiscal year 2005/06 (ended 30
September) the Carl Zeiss Group generated sales totaling EUR 2,433 million.
The Carl Zeiss Group has approximately 11,250 employees, including about
3,400 outside Germany. Further information is available under
www.zeiss.de/press.
