Software facilitates ADME/Tox experiments.

Press Release Summary:



Galileo LIMS v3.1 allows user to plan, design, calculate, graph, and report in vitro ADME/Tox data in single application. It provides automatic results flagging using 3-color system to indicate acceptance, rejection, or flagging of results. Rapid study entry accelerates entry of concentration or raw data from analytical instrument into LIMS. Software supports PAMPA permeability studies for early screening of compounds, and IC50 shift experiments to elucidate enzyme activation.



Original Press Release:



Visualization, Automation Enhance Efficiency of Thermo's Galileo LIMS for ADME/Tox Experiments



Philadelphia, PA (October 05, 2005) - Thermo Electron Corporation (NYSE:
TMO) announces the availability of Galileo LIMS v 3.1, providing additional functionality to increase efficiency in the demanding high-throughput environment of in vitro ADME/Tox discovery laboratories.

Highlights of the latest release of this unique laboratory information management system (LIMS) include:
o automatic results flagging, using a three-color system to indicate acceptance, rejection or flagging of results;
o rapid study entry to accelerate the entry of concentration or raw data from analytical instrument into the LIMS;
o the addition of "IC50 shift" - a new experiment type to elucidate enzyme inactivation;
o and support for PAMPA permeability studies that are important in early screening of compounds.

In addition, Galileo now interfaces with more analytical instruments, including a bi-directional digital interface to Xcalibur v 1.4 and 2.0, the controlling software for Thermo's line of mass spectrometers.

"Galileo was designed to eliminate the tradeoff between rigorous results at reduced throughputs or increased capacity via standardization on a single workflow," said Joel Usansky, Ph.D., Galileo product manager. "The latest version of Galileo provides the necessary functionality to increase each user's productivity while remaining flexible for the early discovery environment. In Galileo, they will find calculations for standard ADME experiments, templates and charting galleries that visually display results for rapid data review and decision-making. This LIMS eliminates the need to transfer data to multiple external applications such as spreadsheet, graphical and curve-fitting software."

Introduced in mid-2003, Galileo is a fully integrated system that allows users to plan, design, calculate, graph and report in vitro ADME/Tox data in a single application. The experimental procedure and definition of samples, creation of analytical run worklists, interfacing to analytical instruments such as LC-MS and plate readers, creation of calibration curves, and calculation of final results can be performed by Galileo and saved to the Oracle database.

Many features make the Galileo solution easy to use: multi-site scalability, integrated scheduling capabilities, adaptable data reduction and analysis, powerful curve fitting and graphing, creation of result tables, and document management.

Please send all leads from this editorial FAO: Kathleen Beaulieu on e-mail marketing.informatics@thermo.com For more information please call Thermo Electron on 866-463-6522 or e-mail marketing.informatics@thermo.com

About Informatics
Thermo is the worldwide leader in laboratory software and related services, providing enterprise-wide, multi-laboratory solutions that have become the corporate standard at leading organizations. Our LIMS and CDS are facilitating laboratory data in the world's leading pharmaceutical companies, petrochemical and chemical plants, food and beverage manufacturers, and other major industries. To support our global installations, Thermo provides implementation, validation, training, maintenance and support from the industry's largest worldwide informatics services network.

About Thermo Electron
Thermo Electron Corporation is the world leader in analytical instruments.
Our instrument solutions enable our customers to make the world a healthier, cleaner and safer place. Thermo's Life and Laboratory Sciences segment provides analytical instruments, scientific equipment, services and software solutions for life science, drug discovery, clinical, environmental and industrial laboratories. Thermo's Measurement and Control segment is dedicated to providing analytical instruments used in a variety of manufacturing processes and in-the-field applications, including those associated with safety and homeland security. Based near Boston, Massachusetts, Thermo has revenues of approximately $2.7 billion, and employs approximately 11,000 people in 30 countries. For more information, visit www.thermo.com.

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