Sample Preparation Kit facilitates systems biology studies.

Press Release Summary:



Based on systems biology sample preparation method, ProteoSolve-SB Pressure Cycling Technology-dependent kit provides simultaneous extraction, isolation, and fractionation of nucleic acids, proteins, and lipids from animal and plant samples routinely used in laboratory research. Kit contains proprietary reagents, consumable processing containers, and instructions for use, and is intended to be used with Company's patented PCT Sample Preparation System.



Original Press Release:



Pressure BioSciences, Inc. Releases Novel, PCT-Dependent Sample Preparation Kit for Systems Biology Studies



SOUTH EASTON, Mass., Aug. 20 /- Pressure BioSciences, Inc. (NASDAQ:PBIO) ("PBI" or the "Company") today announced the release for sale of ProteoSolve-SB, a novel, pressure cycling technology ("PCT")-dependent kit for the simultaneous extraction, isolation, and fractionation of nucleic acids (DNA and RNA), proteins, and lipids from animal and plant samples routinely used in laboratory research. This patent-pending kit was released earlier this week at the International HUPO (Human Proteomic Organization) Meeting, being held in Amsterdam, The Netherlands. It contains proprietary reagents, consumable processing containers (PULSE Tubes), and instructions for use, and is intended to be used with the Company's patented PCT Sample Preparation System. The kit is based on the unique approach to a "systems biology" sample preparation method that was first unveiled earlier this year by the PBI scientific team in collaboration with Dr. Alexander Ivanov of the Harvard School of Public Health at the annual meetings of US HUPO and the Association of Biomolecular Research Facilities (ABRF).

Systems biology (SB) is the study of the complex interactions of biological systems within an organism. This allows the researcher to consider the integrated effects and emergent properties of many complex biological systems, which in turn should result in the more rapid development of diagnostics and therapeutics. Integral to the SB approach is the study of nucleic acids, proteins, and lipids from the same biological sample. Very few techniques currently available allow for the efficient concomitant extraction, isolation, and fractionation of these important bio-molecules; therefore, scientists must rely on mutually incompatible sample preparation methods that result in costly, time-consuming, and problematic processing issues.

Dr. Vera Gross, Senior Scientist in R&D for PBI, and one of the inventors of the kit, said: "There are several methods available today that offer scientists the important ability to get proteins, DNA, and RNA from the same sample. However, unlike nearly all of these kits, ProteoSolve-SB does not use inefficient columns or harsh detergents that can cause serious problems with protein recovery. Instead, ProteoSolve-SB uses organic solvents that can be easily and quickly removed, and that have been shown to offer enhanced protein recovery over current methods. Furthermore, unlike ProteoSolve-SB, none of the methods available today extract lipids in addition to proteins and nucleic acids from the same biological sample -- lipid extraction is very important, and integral to a systems biology approach."

Mr. Richard T. Schumacher, Founder, President, and CEO of PBI commented: "Our number one priority is to drive the installed base of PCT Sample Preparation Systems throughout the life sciences area. We believe the best way to achieve this goal is to develop PCT-dependent products that can improve scientific research and enhance the opportunity for discovery. ProteoSolve-SB, and the recently released FT500-ND PULSE Tube and the Proteolysis (Trypsin)-PrEP application, were all designed with these important objectives in mind. To this end, we believe that our PCT-dependent products have already begun to fill unmet needs in critical, growing areas of scientific research. This in part accounts for the record number of installations already achieved in the current quarter, and the expectation that we will install 40 or more PCT Systems in 2008 as compared to 20 in 2007, as announced on August 14th."

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (PBI) is a publicly traded company focused on the development of a novel, enabling technology called Pressure Cycling Technology (PCT). PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels (up to 35,000 psi and greater) to control bio-molecular interactions. PBI currently holds 13 US and 6 foreign patents covering multiple applications of PCT in the life sciences field, including such areas as genomic and proteomic sample preparation, pathogen inactivation, the control of chemical reactions, immunodiagnostics, and protein purification.

Visit us at our website http://www.pressurebiosciences.com/

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