Researchers Present New Work on Cohesive Pharmaceutical Powders Using the Morphologi G3 Particle Characterization System
Collaborative studies described in poster at 2009 AAPS Annual Meeting and Exposition
15 October 2009: Malvern, UK: Contributing to the poster presentations at the 2009 AAPS Annual Meeting and Exposition (8-12 November 2009: Los Angeles, USA), researchers from Solvay Pharmaceuticals Inc and Malvern Instruments will present details of a study to examine particle size, shape and distribution data for equivalency testing of a highly cohesive drug substance manufactured at two different sites.
Using Malvern's Morphologi G3 automated image analysis system for particle characterization, the team looked at the effects of different dispersion conditions including dispersion pressure, foil thickness, dispersion apparatus, and evaporative techniques. The results were compared with data from optical microscopy and laser light scattering methods. The authors go on to discuss the importance of method development in determining the techniques and parameters necessary to generate reproducible and accurate data. They highlight the usefulness of the Morphologi G3's ability to selectively filter data, ensuring that analyses are performed only on the particles of interest.
Automated image analysis using the Morphologi G3 offers high resolution measurement of particle size and particle shape through direct image capture. It delivers excellent results for a wide range of particle sizes, typically from below 1 µm up to several thousand. It is ideal for many sample types including those, such as dry powders, creams and gels, and particles on filters, that may be difficult to characterize by other means.
The system will be demonstrated on the Malvern Instruments Booth # 813, together with the latest Zetasizer systems for the measurement of proteins and nanosized particles, and Malvern's advanced range of Viscotek Gel Permeation/Size Exclusion chromatography systems for protein and polymer analysis. Visitors will be able to explore other systems in the Malvern materials characterization range via interactive displays on the booth. Malvern specialists will be available throughout to discuss individual material characterization needs. www.malvern.com
About Malvern Instruments
Malvern Instruments provides a range of complementary materials characterization tools that deliver inter-related measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Analytical instruments from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to nanomaterials and delicate macromolecules. A broad portfolio of innovative technologies is combined with intelligent, user-friendly software. These systems deliver industrially relevant data enabling our customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging).
Particle size, particle shape, zeta potential, molecular weight, chemical composition and rheological properties measurements are now joined by advanced chromatography solutions (GPC/SEC), extending Malvern's technologies for protein molecular weight, size and aggregation measurements, and synthetic polymer molecular weight and distribution. The company's laboratory, at-line, on-line and in-line solutions are proven in sectors as diverse as cement production and pharmaceutical drug discovery.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com
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Fax: +1 508 768 6403
marisa.fraser@malvern.com
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salesinfo@malvern.com
