Research Tools allow consistent processing of mature microRNA.

Press Release Summary:



Suited for phenotypic studies, drug discovery applications, or to further studies of microRNA biology, miRIDIAN shMIMIC Lentiviral microRNAs can induce stable over-expression of functional mature microRNA mimics by harnessing endogenous microRNA processing pathway. shMIMIC microRNA is delivered into cell using purified, high-titer lentiviral particles, facilitating delivery even in difficult-to-transfect cell types such as primary cells, stem cells, and non-dividing cell types.



Original Press Release:



Thermo Fisher Scientific Introduces the First Rationally Designed Research Tool for Stable Expression of Mature MicroRNA



shMIMIC lentiviral microRNA permits delivery even in difficult-to-transfect cells

LAFAYETTE, Colo., - Thermo Fisher Scientific Inc., the world leader in serving science, today launched a new product for the long-term over-expression of mature microRNA. Thermo Scientific miRIDIAN shMIMIC Lentiviral microRNAs incorporate innovative design strategies that allow consistent processing of the mature microRNA and enhanced specificity, making them ideal for a variety of microRNA research applications.

miRIDIAN® shMIMIC(TM) Lentiviral microRNAs can induce stable over-expression of functional mature microRNA mimics by harnessing the endogenous microRNA processing pathway. The shMIMIC microRNA is effectively delivered into the cell using purified, high-titer lentiviral particles; this facilitates delivery even in difficult-to-transfect cell types such as primary cells, stem cells and non-dividing cell types. The shMIMIC microRNA is then processed in the same way as an endogenous microRNA gene, resulting in over-expression of the microRNA mimic and subsequent down-regulation of the microRNA target gene(s).

shMIMIC Lentiviral microRNAs incorporate unique design elements that are critical for accurate processing and efficient downstream activity of only the mature microRNA of interest while minimizing the effects of the star (*) strand. shMIMIC lentiviral microRNAs have been effectively used by Thermo Fisher Scientific scientists to produce phenotypic responses to microRNA target gene down-regulation. Such studies provide valuable insight into microRNA participation in critical biological and disease pathways.

shMIMIC Lentiviral microRNAs are available in high-titer, purified lentiviral particle format for each human microRNA in the miRBase microRNA database. These unique, transduction-ready microRNA tools are ideal for phenotypic studies, drug discovery applications or to further studies of microRNA biology.

For further information about Thermo Scientific miRIDIAN shMIMIC Lentiviral microRNAs, or to search for the shMIMIC microRNA specific to your microRNA of interest, please visit www.thermo.com/shMIMICmicroRNAs.

Thermo Scientific is part of Thermo Fisher Scientific Inc., the world leader in serving science.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of more than $10 billion, we have approximately 35,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit www.thermofisher.com.

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