Pocket-Size Instrument automates electrophysiology.
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Press Release Summary:
Port-a-Patch© throughput-optimized patch-clamp automat uses technology based on micro-structured chip that facilitates electrophysiological experiments for ion channel screening. With compound consumption in microliter range, workstation performs measurements in automated manner and obtains whole dose response curves from single-cell experiments. Fluid exchange rate on chip allows for experiments on voltage-gated as well as ligand-gated ion channels.
Original Press Release:
Nanion Shrinks Electrophysiology to Pocket Size
While the classical patch-clamp technique is the gold standard for ion channel investigations, it is a labour-intensive method performed only by skilled scientists. It hence fails to meet the requirements of pharmaceutical drug testing in regards to cost and time employed per data point.
With the miniaturized Port-a-Patch©, Nanion offers not only its first generation of throughput optimized patch-clamp automats, but also the world's smallest patch-clamp workstation. This innovative drug discovery technology based on a micro-structured chip greatly facilitates electrophysiological experiments for ion channel screening. As the measurements are performed in an automated manner, it makes patch clamp available also to non-electrophysiologists.
The Port-a-Patch© is a complete patch clamp setup with minimum foot print and very low maintenance requirements. It uses Nanions planar patch clamp chips and provides high quality data on any ion channel target. Experiments are performed on a single cell at a time, whereby whole dose response curves can be obtained from a single cell. Due to its miniaturization, compound consumption is extremely low (in the µl range). The Port-a-Patch© enables a fast fluid exchange on the chip, allowing for experiments not only on voltage gated, but also on ligand gated ion channels. A software controlled perfusion system (8 channels) is also available from Nanion.
With the Port-a-Patch©, Nanion offers a valuable tool for target validation and safety pharmacology (hERG screening), that ideally complements other high throughput screening techniques.
For more information, please contact us at info@nanion.de , visit our website at www.nanion.de , or read our latest newsletters:
http://www.nanion.de/pdf/NanionNotes1.pdf
http://www.nanion.de/pdf/NanionNotes2.pdf
