Patch Clamp Workstation suits cellular electrophysiology.
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Press Release Summary:
Robotic multi-channel patch clamp workstation NPC©-16 patchliner© uses microstructured glass chips and employs microfluidics to enable perfusion. Success rates of 60-80% are achieved in gigaseal formation and stable whole cell recording. It allows application of compounds in laminar flow channels and also enables intracellular perfusion to make both sides of cell membrane accessible by pipetting robotics.
Original Press Release:
Nanion Technologies Launches Second Generation Automated Patch Clamp Workstation NPC©-16 Patchliner ©
Nanion has successfully established its entry level device for automated patch clamp, the NPC©-1 port-a-patch© and is now launching its second generation instrumentation, the NPC©-16 patchliner©. The patchliner© is a robotic multi-channel patch clamp workstation for high quality cellular electrophysiology with increased throughput capabilities. The system uses Nanions microstructured glass chips and employs microfluidics to enable fast and precise perfusion. High success rates in gigaseal formation and stable whole cell recording of 60-80% are routinely achieved. The patchliner© not only allows the fast application of compounds in laminar flow channels (~50ms, ideally suited for ligand gated channels), but even enables intracellular perfusion, so both sides of the cell membrane are accessible by pipetting robotics.
The patchliner© builds on the success of the port-a-patch© technology, offering vast experimental flexibility with high quality and increased throughput.
about Nanion:
Nanion Technologies (Germany) is a spin-off from the Center for Nanoscience (CeNS) of the University of Munich and is dedicated to providing flexible and customized solutions for ion channel research both in industry and academia. With the miniaturized NPC©-1 port-a-patch©, Nanion offers the world's smallest patch-clamp workstation. This innovative drug discovery technology makes patch clamp available also to non-electrophysiologists. The NPC©-16 patchliner© additionally addresses the higher throughput requirements for ion channel screening and is a valuable tool for target validation, lead optimization and safety pharmacology (hERG screening).
For more information, please contact us at info@nanion.de or see also www.nanion.de
Links:
Nanion: www.nanion.de
NPC-16 patchliner: www.nanion.de/pdf/patchliner.pdf
Port-a-Patch: www.nanion.de/pdf/port-a-patch.pdf
Nanion Notes IV: www.nanion.de/pdf/NanionNotes4.pdf
