Mass Spectrometry System analyzes complex samples.

Press Release Summary:

Designed for researchers who need to characterize and define complex samples, Waters® Synapt(TM) High Definition MS(TM) (Mass Spectrometry) System differentiates ions by molecular mass, size, and shape. It employs Waters Triwave(TM) technology, which offers methodology for combining ion mobility-based measurement and separations with mass quadrupole time-of-flight MS. Operational control and data acquisition and processing are performed through Waters MassLynx(TM) Software.

Original Press Release:

Waters Debuts New Class of Mass Spectrometry Technology at ASMS 2006

Unleashes the Power of MS to Detect What Conventional Technology Leaves Behind

SEATTLE, June 1 -- Waters Corporation (NYSE:WAT) introduced a first-of-its-kind mass spectrometry technology that differentiates sample ions by mass, size and shape at the 54th American Society of Mass Spectrometry Conference on Mass Spectrometry, May 28 - June 1. The Waters(R) Synapt(TM) High Definition MS(TM) (HDMS(TM)) System is designed for researchers working at the limits of conventional mass spectrometry (MS) and who need to further characterize and define complex samples.

The Synapt HDMS system employs new ion-mobility technology and software to enable the analysis of sample ions differentiated by size and shape, as well as molecular mass. This additional dimension of separations fidelity leads to improved specificity and sample definition, meaning scientists can extract more information about their samples including the detection of previously undetected constituents.

A key feature of this new system is the patented Waters Triwave(TM) technology, a unique methodology for combining highly-efficient, ion-mobility based measurement and separations with high-sensitivity performance, accurate mass quadrupole time-of-flight mass spectrometry. Operational control and data acquisition and processing are performed through Waters MassLynx(TM) Software.

Shipments of the new mass spectrometer are expected to begin in the second half of 2006.

Waters collaborator Professor Carol Robinson of the University of Cambridge, Cambridge, England, has evaluated the technology, and in a peer-reviewed article in Science magazine(1) she and her colleague, post-doctoral researcher Bandon Rutolo, disclosed how the new technology helped to convincingly demonstrate that gas phase structures of intact multi-protein complexes, though devoid of bulk solvent, are essentially equivalent to native solvated structures.

For more information on Waters Synapt High Definition MS System, visit

About Waters Corporation

Waters Corporation holds worldwide leading positions in three complementary analytical technologies -- liquid chromatography, mass spectrometry and thermal analysis. These markets account for approximately $5.0 billion of the overall $20 - $25 billion analytical instrument market.

Waters is a registered trademark and Synapt, High Definition MS, HDMS, MassLynx and Triwave are trademarks of Waters Corporation.

(1). Ruotolo, B.T. et al., Evidence for Macromolecular Protein Rings in the Absence of Bulk Water, Science 310, 1658 - 1661 (2005).

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