Malvern Spraytec Aids Dry Powder Inhaler Development

Collaborative studies presented at Respiratory Drug Delivery 2008

9 April 2008: Malvern, UK: At this year's Respiratory Drug Delivery conference (RDD 2008, 11-15 May; Scottsdale, Arizona), a poster presentation from workers at Malvern Instruments and Dr David Morton of the Monash Institute of Pharmaceutical Sciences, describes collaborative studies on the Investigation of Powder Dispersion from a Dry Powder Inhaler Using Laser Diffraction.

Malvern's Spraytec particle characterization system was used for this work, which probed the dynamics of dispersion of various model powder formulations from an inhaler device. The authors conclude that laser diffraction is a screening tool of significance to the Dry Powder Inhaler (DPI) developer, allowing particle size measurements to be made in real time during inhaler actuation and enabling the dispersion process to be followed closely. Spraytec, with its new version software, will be on display throughout the conference.

Spraytec is a high throughput particle characterization system used to analyze a wide range of pharmaceutical and industrial aerosols and sprays. It delivers real-time, high-speed measurements, enabling the detailed characterization of spray behaviour over an extremely wide particle size range. New Spraytec software extends the system's data capture and processing capabilities, providing the automatic calculation of the variability in spray particle size at different time-points during device actuation. This provides additional insight into the operation of inhaler devices, promoting a Quality by Design (QbD) approach to efficient product development.

Dr David Morton and his team at Monash University will also present further novel work* at RDD 2008, demonstrating advances in understanding the fundamental mechanisms inherent in powder dispersion. By applying the fast measurement speeds and wide particle sizing ranges available with the Spraytec system, they have been able to reveal time-dependent de-aggregation and dispersion processes which occur during DPI actuation. Furthermore, they have used this technique to demonstrate how the surface modification of fine lactose powders can provide a substantial improvement in flow properties.

For further information about Spraytec please visit
o Poster presentations at RDD 2008
o Investigating Effects of Surface Modifications on a Mannitol Dry Powder Inhaler Plume by Laser Diffraction
o Investigating the Flow Modification of Fine Lactose Carrier Particles

High resolution image attached or available from Luke Newman, Kapler Communications Ref: MAL/JOB/1528

About Malvern Instruments
Malvern Instruments is a global company that develops, manufactures and markets advanced analytical systems used in characterizing a wide variety of materials, from bulk powders to the latest nanomaterials and delicate macromolecules. Innovative technologies and powerful software produce systems that deliver industrially relevant data enabling customers to make the connection between micro (eg particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging). Malvern laboratory, on-line and in-line solutions are proven in sectors from cement to pharmaceuticals and support the understanding, improvement and optimization of many industrial processes.

Headquartered in Malvern, UK, the company has subsidiary organizations in all major European markets, North America, China, Korea and Japan, key partnerships in India, a global distributor network and a number of applications laboratories around the world.

For press information, please contact
Trish Appleton
Kapler Communications
Knowledge Centre
Wyboston Lakes
Great North Road
MK44 3BY, UK
Tel: +44 (0)1480 479280;
Fax: +44 (0)1480 470343

USA contact:
Marisa Fraser
Malvern Instruments Inc
117 Flanders Road
MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403

Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
Tel: +44 (0) 1684 892456;
Fax: +44 (0) 1684 892789

Sent by: Luke Newman,
Kapler Communications
Our Ref: MAL/JOB/1528
Tel: +44 (0) 1480 479280

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