Malvern Leads with Particle Sizing in Wet Processes at Interphex 2009


3 February 2009: Malvern, UK: Visitors to the Malvern Instruments booth (#1038) at Interphex 2009 (17-19 March; New York) can hear from the company's process specialists how the flexible design of the Insitec LPS wet process particle size analyzer enables it to be tailored for specific applications in the pharmaceutical industry. Featuring alongside the on-line system will be the SyNIRgi near infrared chemical imaging system, the award winning Morphologi G3 automated particle characterization system, and the new Kinexus rheometer platform.

Incorporating a sampler, pre-diluter, cascade diluter and measurement cell, the Insitec LPS is a fully automated particle sizing system that measures particles from 0.1 to 1000 microns in almost any wet stream. Drawing on Malvern's extensive experience, and in close consultation with the customer, each component is tailored to the individual application. Insitec LPS is fully automated and is supplied with the Malvern Link software package, which simplifies operation and facilitates integration with existing control platforms. Operating 24/7 it requires little manual intervention and generates particle size data at the frequency needed for real-time process control. The availability of an Intrinsically Safe (IS) version further extends the system's applicability within the pharmaceutical industry.

In the laboratory, the SyNIRgi near infrared chemical imaging (NIR-CI) system from Malvern is now used widely in the pharmaceutical industry. Its application to solid dosage forms, for example, allows determination of content uniformity, blending efficiency, polymorph distribution, moisture content, contaminant location and coating and layer thickness. It is proving to be a highly valuable tool in the fight against counterfeit drugs, and recent publications highlight its effectiveness in troubleshooting dissolution failure.

Malvern has also added a new capability to its Morphologi G3 automated particle characterization system, enabling the fully automated detection, enumeration and size classification of foreign particulate matter (FPM) collected on a filter. This is especially important in controlling particulate contamination of materials for injection or inhalation. Analysis of FPM on filters has traditionally been the preserve of manual light microscopy, but the Morphologi G3 now brings fully automated image analysis to accelerate characterization and remove any operator subjectivity.

Major advances in rheology measurement are epitomized by the radical new platform from Malvern Instruments. Rheological studies can deliver highly valuable information for the development of a vast array of pharmaceutical products. However, even for experienced users, it can be challenging to measure samples in an appropriate way, and to gain real understanding from the results. Malvern's Kinexus is a revolutionary new rotational rheometer platform. It incorporates technological innovations in the most critical areas of rheometer design, from sample preparation and loading, through measurement set-up and operation, to data analysis and reporting. Adaptive intelligence allows Kinexus to actively guide users at every stage.

To see these products in action visit Malvern Instruments on Booth # 1038 at Interphex. For more details of all the solutions in Malvern's range of systems for materials characterization please go to www.malvern.com

About Malvern Instruments

Malvern Instruments provides a range of complementary materials characterization tools that deliver inter-related measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Analytical instruments from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to the latest nanomaterials and delicate macromolecules. A broad portfolio of innovative technologies is combined with intelligent, user-friendly software. These systems deliver industrially relevant data enabling our customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging).

Particle size distribution, particle shape information, zeta potential, molecular weight, chemical composition, and bulk materials properties can all be determined with instruments from the Malvern range. The company's laboratory, at-line, on-line and in-line solutions are proven in sectors as diverse as cement production and pharmaceutical drug discovery.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com

For press information, please contact:

Trish Appleton, Kapler Communications
Knowledge Centre, Wyboston Lakes, Great North Road,
Wyboston, Bedfordshire, MK44 3BY, UK
Tel: +44 (0)1480 479280; Fax: +44 (0)1480 470343 trish@kapleronline.com

USA contact:

Marisa Fraser, Malvern Instruments Inc.
117 Flanders Road, Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400 Fax: +1 508 768 6403 marisa.fraser@malvern.com

Please send sales enquiries to:

Alison Vines, Malvern Instruments Ltd
Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456; Fax: +44 (0) 1684 892789 salesinfo@malvern.com

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