Malvern Expands Recently Acquired MicroCal Range with Launch of Two New-generation Calorimeters


All new data analysis software in Malvern MicroCal PEAQ-ITC systems delivers greatest accessibility to life science users at every level



Malvern, UK: Malvern Instruments has launched two new-generation isothermal titration calorimeters (ITC), advancing its recently acquired MicroCal range to further support life science researchers studying biomolecular interactions. The new manual Malvern MicroCal PEAQ-ITC and fully automated Malvern MicroCal PEAQ-ITC Automated systems are designed to deliver the enhanced functionality and robust performance now demanded of this essential tool.



ITC allows the label-free study of a wide variety of molecular interactions and the Malvern MicroCal PEAQ-ITC and PEAQ-ITC Automated systems deliver exceptional sensitivity and outstanding data quality at high speed. Redesigned software ensures intuitive operation while automated data analysis means even non-experts can interpret with confidence. Options for walk-away automation offer quicker screening, faster hit validation and greater laboratory efficiency, and Malvern remains the only producer of a fully automated ITC system.



These new ITC systems are the product of more than 30 years of MicroCal experience and market leadership in microcalorimetry and build on long-established MicroCal ITC technology. As part of Malvern Instruments, the MicroCal product range is now supported around the world by Malvern’s extensive network of dedicated technical and application specialists, as well as via the company’s many helpdesks and through the provision of multiple online resources.



Malvern MicroCal PEAQ-ITC

Manual ITC systems are widely used in basic life science research, structure function analysis, protein research and drug target characterization. Incorporated in the new systems are user-friendly guided workflows with embedded help videos that give any level of user the ability to generate high quality data. In addition, high signal to noise gives confidence in data quality and in the relevance of the affinity and thermodynamic parameters generated. An all new data analysis software package can simulate experiment design, provide batch evaluation of large data sets and automated assessment of data quality, while its streamlined interface improves workflow by guiding the user to final figures and presentation quality graphs quickly and easily. In terms of hardware, a new automated washing system uses detergent to clean the sample cell and titration syringe, minimizing day-to-day maintenance and assisting the production of high quality reproducible data. Furthermore, this manual system is upgradeable to an automated ITC.



Malvern MicroCal PEAQ-ITC Automated

The Malvern MicroCal PEAQ-ITC Automated is a fully automated ITC system that will replace the current Malvern MicroCal Auto-ITC200. Its robust new design is coupled with the same all new data analysis package featured in the manual system. Such full automation has applications in many laboratories, but is ideally suited to industrial and other core facilities involved in small molecule drug discovery where large-scale target identification, hit validation and lead optimization are undertaken. By combining the best possible data quality and reproducibility with high speed, unattended operation, the Malvern MicroCal PEAQ-ITC Automated can provide early indications of high quality hits while freeing researchers for other tasks.



To find out more about isothermal titration calorimetry visit the ITC pages on the Malvern website http://www.malvern.com/itc



For details of the new Malvern MicroCal ITC products go to http://www.malvern.com/peaq-itc



Malvern, Malvern Instruments and MicroCal are registered trademarks of Malvern Instruments Ltd



About Malvern Instruments

Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.



Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.



Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, nanoparticle size and count, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.



Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, Mexico, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.

www.malvern.com



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