Image Analyzer from Malvern Offers Reference Technique for Sizing HPLC Column Materials


28 July 2009: Malvern, UK: Malvern Instruments has published work demonstrating how the Sysmex FPIA-3000 image analysis-based particle characterization system provides a reference method for validating particle size measurements of the porous silica materials used in high performance liquid chromatography (HPLC) columns. An application note detailing this is available on the Malvern website: www.malvern.com/ESZ

Particle size of column materials is critical in both preparative and analytical HPLC. The majority of applications require particles between 3 and 30 µm, but the high porosity of the silica particles presents a challenge for size measurement. Electrozone sensing (EZS) is the established method, and is reliable provided the instrument is mass calibrated to compensate for the porosity of the particles.

Characterizing silica particles using automated image analysis provides confirmation of the mass calibration supporting ESZ measurements, while delivering further additional imaging data on the particles under observation.

Visit www.malvern.com/ESZ for more information.

About Malvern Instruments

Malvern Instruments provides a range of complementary materials characterization tools that deliver inter-related measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Analytical instruments from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to nanomaterials and delicate macromolecules. A broad portfolio of innovative technologies is combined with intelligent, user-friendly software. These systems deliver industrially relevant data enabling our customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging).

Particle size, particle shape, zeta potential, molecular weight, chemical composition and rheological properties measurements are now joined by advanced chromatography solutions (GPC/SEC), extending Malvern's technologies for protein molecular weight, size and aggregation measurements, and synthetic polymer molecular weight and distribution. The company's laboratory, at-line, on-line and in-line solutions are proven in sectors as diverse as cement production and pharmaceutical drug discovery.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com

For press information, please contact:

Trish Appleton,

Kapler Communications

Knowledge Centre, Wyboston Lakes, Great North Road,

Wyboston, Bedfordshire, MK44 3BY, UK

Tel: +44 (0)1480 479280;

Fax: +44 (0)1480 470343

trish@kapleronline.com

USA contact:

Marisa Fraser, Malvern Instruments Inc.

117 Flanders Road, Westborough, MA 01581-1042 USA

Tel: +1 508 768 6400 Fax: +1 508 768 6403

marisa.fraser@malvern.com

Please send sales enquiries to:

Alison Vines, Malvern Instruments Ltd

Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ UK

Tel: +44 (0)1684 892456; Fax: +44 (0)1684 892789 salesinfo@malvern.com

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