High-Speed Chromatography Columns use Fused-Core® particle design.

Press Release Summary:

Based on Fused-Core particle design, Ascentis® Express 2.0 micron high-speed ultra high-performance liquid chromatography (UHPLC) columns deliver 300,000 plates/m efficiency. Susceptibility to column plugging is minimized due to 1.0 m frits on column inlet. While columns can be used up to 14,500 psi, design reduces back pressure production and subsequent concerns as well as column frictional heating and instrument wear associated with very small particles.

Original Press Release:

Sigma-Aldrich Expands the Ascentis® Express U/HPLC Column Line with Addition of 2.0 Micron Fused Core® Particle Columns

ST. LOUIS -- Sigma-Aldrich Corporation (NASDAQ: SIAL) announced today that Supelco, its innovative analytical products and services research business, has launched the Ascentis(®) Express 2.0 micron, a high-speed, ultra high-performance liquid chromatography (UHPLC) column platform based on the proven Fused-Core(® )particle design.

Ascentis Express 2.0 micron Fused-Core particles are designed to provide UHPLC performance, while addressing the disadvantages inherent in existing sub-2 micron UHPLC columns. Ascentis Express 2.0 UHPLC columns deliver 300,000 plates per meter efficiency.  Furthermore, Ascentis Express 2.0 micron columns are less susceptible to column plugging due to the large 1.0  m frits on the column inlet. While Ascentis Express columns can be used up to 1,000 bar (14,500 psi), they will produce approximately 20% lower back pressure than most commercially available sub-2  m UHPLC columns under the same conditions, reducing concerns of column frictional heating and instrument wear and tear associated with very small particles.

"Ascentis Express 2.0 is the outcome of listening to customers' needs for the UHPLC market," said Wayne K. Way, Ph.D., Marketing Manager for HPLC at Sigma-Aldrich. "Ascentis Express 2.0 micron UHPLC columns deliver the speed and efficiency needed by today's research and applied markets for use in areas such as pharmaceutical drug development and clinical diagnostics and testing."

With this launch, the Ascentis Express product line has expanded to 2.0, 2.7 and 5 micron particle U/HPLC columns. The Ascentis Express product line is scalable from UHPLC to legacy HPLC systems. The scalability assures researchers that their methods can be seamlessly transferred across campus or around the world.

Available in 11 different dimensions and two introductory phases, C18 and F5, Ascentis Express 2.0 is part of Sigma Aldrich's ongoing objective to increase the research community's access to premier products based on innovative technologies.

About Supelco:  Supelco is a Sigma-Aldrich business that represents the Company's leadership in innovative research products and services for the global analytical market which offers a premier array of proven tools and consumables used by researchers in scientific investigation, quality control and manufacturing. Supelco offers solutions for the analysis of drugs in biological fluids, the chromatographic purification of chemicals, the analysis of foods and beverages, the identification of pollutants in the environment, and more.

About Sigma-Aldrich:  Sigma-Aldrich, a leading Life Science and High Technology company focused on enhancing human health and safety, manufactures and distributes more than 230,000 chemicals, biochemicals and other essential products to more than 1.4 million customers globally in research and applied labs as well as in industrial and commercial markets. With three distinct business units -- Research, Applied and SAFC Commercial -- Sigma-Aldrich is committed to enabling science to improve the quality of life. The Company operates in 37 countries, has more than 9,000 employees worldwide and had sales of $2.7 billion in 2013. For more information about Sigma-Aldrich, please visit its website at www.sigma-aldrich.com.

Sigma-Aldrich and Ascentis are registered trademarks of Sigma-Aldrich Co. LLC. Fused Core is a registered trademark of Advanced Materials Technology, Inc.


Jen McMahon

+ (1) 314-236-0986


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