DDL22 Poster Reports on the Power of Imaging in OINDP Development


Malvern, UK: Imaging specialist Dr Deborah Huck from Malvern Instruments will present a poster at Drug Delivery to the Lungs 22 (7-9 Dec, Edinburgh, Scotland) exploring how automated imaging can be used alongside cascade impaction to support the development of inhaled drug products. Hanne Kinnunen of the Department of Pharmacy and Pharmacology, University of Bath (UK), will also reference work with the Morphologi G3-ID in her presentation 'Effect of lactose fines on the de-agglomeration behaviour of dry powder inhaler formulations', on Friday 9 December.

Dr Huck's poster will report on work performed with the Morphologi G3-ID system to examine the size and shape of the fractions delivered by cascade impaction.

Cascade impaction is used to measure the aerodynamic particle size distribution of the active ingredient of orally inhaled and nasal drug products (OINDPs). Normally material collected on each impactor stage is analyzed by HPLC to determine the amount of active present. This gives essential compositional data but no information about the morphology or structure of the particles present. The poster reports on this additional step and the extra insight the data provides.

Since the Morphologi G3-ID combines automated imaging with Raman spectroscopy, it offers further scope to add chemical identification to the particle size and shape data. It is anticipated that this additional information will in future provide new insight into the dispersion mechanisms occurring during drug delivery and support their improvement.

For further information about the Morphologi G3-ID please go to: www.malvern.com/raman or visit the Malvern stand at DDL22.

Malvern, Malvern Instruments and Morphologi are registered trademarks of Malvern Instruments Ltd

About Malvern Instruments

Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical identification. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.

Malvern's measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com

USA contact:

Marisa Fraser, Malvern Instruments Inc.

117 Flanders Road, Westborough, MA 01581-1042, USA

Tel: +1 508 768 6400

Fax: +1 508 768 6403

marisa.fraser@malvern.com

Please send sales enquiries to:

Alison Vines, Malvern Instruments Ltd.

Enigma Business Park, Grovewood Road, Malvern, Worcestershire WR14 1XZ, UK

Tel: +44 (0) 1684 892456

Fax: +44 (0) 1684 892789

salesinfo@malvern.com

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