Contained Vessel Chargers handle highly potent slurries, powders.

Press Release Summary:

Designed to minimize contamination risk, SlurryBox enables charging of highly potent slurry into reactors through pressured vessels. It can be used as central dispensing and weighing station servicing multiple reactors. Engineered to charge reactor from different size drums containing potent powder, Multi-Drum Monocell achieves OEL of less than 1 µg/m³ 8 hr TWA. Pneumatic raise and lower system allows multiple height adjustment with 98° rotating actuator for 50 kg max lift.

Original Press Release:

Contained Charging for High Potency

Given the trend for ever increasing potency of pharmaceutical powders, project engineers are continually faced with the challenge of upgrading the containment of their charging process to a new or existing reactor.

As a pioneer of containment, Powder Systems Limited (PSL) has refined a complete range of contained vessel charging solutions that will protect both the operator and the product down to nanograms containment level.

Our glovebox isolators are suitable for charging slurry and powder into reactors and other vessels from small-scale synthesis to bulk production. Many aspects have to be taken in consideration prior to design the appropriate charging solution:

- Assessment of powder transfer method and powder handling characteristics

- Evaluation of materials handling including manual or mechanically assisted requirements

- Vessel isolation method

- Assessment of pressures or steam in place requirements


PSL recently enhanced their SlurryBox to enable charging of highly potent slurry into reactors through pressured vessels. The SlurryBox can be used as a central dispensing and weighing station servicing numerous reactors within the manufacturing site.

The vessels are specifically built for high potent process with CIP spray ring to clean each nozzle and minimum product retention design. The powder is charged safely into the vessel from the SlurryBox, and then liquid is brought in through nozzles to create the slurry. This method presents less risk of contamination with high potent powder as the product is moved within the site in a liquid state. Finally, the slurry is directly transferred from the vessel into the reactor under pressure for a better flow control. This also avoids using valves which involve a more complexes cleaning procedure.

The facilities delivered last year also enables recovery of catalysts and carbon from the bag filter in a contained environment.

Multi-Drum Monocell

The multi-drum monocell is specifically engineered to charge a reactor from different size drums containing potent powder.

The monocell drum hoist is a pneumatic raise and lower system for multiple height adjustment with a 98 degree rotating actuator for a 50kg maximum lift. The docking ring seals the drum chamber to the monocell using inflatable seals. The operator can then safely open the back door and reach into the drum without effort. The enhanced ergonomics allows minimum manual handling from the operator.

The Multi-Drum Monocell achieves an OEL of less than 1 µg/m³ 8 hours Time Weighted Average (TWA).

Contained vessel charging design features available:

- cGMP

- Systems to handle bags, drums, Rapid Transfer Ports (RTPs), split valves

- Variable drum sizes accommodated

- Drum vapour control available

- Supply of hoists and docking systems

- PSL low profile pressure-rated plug valves

- Nitrogen purge system

- Clean-in-place (CIP)and Steam-in-place (SIP) system

- Safe change HEPA filters (push-push) including remote design

- Lift up windows available for ease of maintenance

- Functional safety interlocks

- Ergonomically located display panel

- Designed according to required universal regulations

- Standard 4mm stainless steel main body construction

- Mobile designs

- Available for small-scale synthesis application

PSL press contact:

Camille Flores – – +44 (0)151 448 7741

Company information:

Powder Systems Limited (PSL)

+44 (0)151 448 7700

About PSL:

Powder Systems Ltd (PSL) provides a full range of filtration, drying and contained powder handling products to worldwide industry leaders including Pfizer, GSK and BMS. From small-scale production to full process systems PSL's isolation products provide containment to nanogram levels for handling highly potent APIs.

PSL provides a full service that includes: OEL testing, installation, operator training, aftercare, reliable spare parts and emergency call out to anywhere in the world. PSL has been established for 23 years and has offices and distributors worldwide to easily assist their global customer base.

More from Electronic Components & Devices

All Topics