Bruker Announces High-Performance and Cost-Effective NMR Solutions for the Pharmaceutical and Chemical Industries

PITTSBURGH – At the 57th Experimental Nuclear Magnetic Resonance Conference (, Bruker (NASDAQ: BRKR) is showcasing several innovative drug discovery, drug development and process control solutions for small molecule NMR characterization in the chemical and pharmaceutical industries.

    --  AssureNMR with CRAFT:  Now available with Complete Reduction to

        Amplitude Frequency Table (CRAFT) and tools for biologics analysis

        AssureNMR™ 2.1 reveals small structural and compositional changes in

        complex materials such as biofluids, culture media and biologics,

        important for product quality control. CRAFT delivers matching and

        quantification of key metabolites, based on targeted fingerprinting.

        Metabolite identification is enhanced in AssureNMR by the ability to

        incorporate the large, public Human Metabolome Data Base (HMDB) and

        DrugBank database, each containing over 900 NMR spectra of metabolites

        and drug compounds, respectively.  Anthony Ribeiro, Ph.D., of Duke

        University Medical Center said: "These features represent major

        enhancements to the AssureNMR software package for the detailed analysis

        of biofluid systems."

    --  Experiment Selector: The latest release of TopSpin® software,

        TS3.5pl6, features a new, user-friendly GUI which provides easy access

        to vast experiment libraries including standard Bruker pulse sequences

        and user generated experiment libraries for both industrial and academic

        users. The GUI enables users to build and organize their own customized

        experiment libraries via simple drag and drop, provides multiple options

        for experiment setup and optimization, enables script based parameter

        adjustment, and makes the setup of sophisticated experiments simple and


    --  Free TopSpin Processing:  In order to provide students, instructors and

        researchers with unlimited access to the best tools for off-line NMR

        processing, Bruker is making their market leading NMR processing

        software TopSpin available free of charge for all academic users.  In

        addition to Bruker NMR data, the software is able to process data

        acquired on Agilent, Varian and JEOL systems, and it can read data

        provided in JCAMP format.  For a download of TopSpin software, please go


    --  SmartDriveNMR:  Bruker is setting new standards for NMR solutions with

        its 'Intelligent NMR Spectrometer Initiative'.  The goal of this project

        is to incorporate  automatic, intelligent decision making into the

        spectrometer.  SmartDriveNMR - the further step in this direction -

        decides on-the-fly for an optimized set of NMR experiments delivering

        the most information with the best quality within a user defined

        timeframe for a given spectroscopic problem.  SmartDriveNMR saves

        spectrometer time by automatically running only these experiments that

        add the most value to solve a given problem.  SmartDriveNMR is

        seamlessly integrated into the industry-standard routine NMR acquisition

        software IconNMR to provide solutions for structure consistency

        analysis, which are common in most NMR service labs.

    --  Lab2NMR:  This adaption of the automation and scheduling system

        lab2lab™ ( allows NMR samples in modern, larger

        analytical service organizations to be transported to the instrument via

        the lab2lab pipe system.  Samples are submitted for analysis directly

        from the chemist's bench in standard vials.  The lab2lab system

        transports these vials to remote analytical NMR instrument via a pipe

        system.  Once at the instrument, lab2NMR accepts the sample, prepares it

        for NMR measurement and schedules the experiment. This system improves

        the efficiency and the load-factor, thus enhancing NMR productivity.

    --  Dr. Harald Schröder at Novartis Basel stated: "With the latest addition

        of Lab2NMR, our well established lab2lab system for rapid, flexible and

        hassle-free open access routine analytics became even more productive.

        Now, chemists can send off samples for NMR analysis as easily and with

        the same interface as they are used to from LC-MS.  The resulting

        spectra are in their inbox much faster than previously, when the chemist

        had to find the closest available open access system."

    --  New Automation Tools: The new SampleCase-heated is designed for work in

        polymer research. It is capable of keeping up to 24 samples at

        temperatures of up to 125°C, keeping polymers liquid and ready for

        measurement.  Bruker also announces the next-generation cooling rack for

        the SampleJet autosampler. This new module allows for individual cooling

        and temperature regulation of each of the five sample racks. With the

        additional 96 spinner-less open access sample positions, the SampleJet

        is the best choice for metabolomics and bio-screening applications.

    --  Bruker Fusion-SV 1.1: The new edition of the Bruker Fusion-SV 1.1

        automated structure verification solution for small molecules in pharma

        and chemistry research integrates high-resolution, accurate mass

        ESI-QTOF mass spectrometry for automated chemical formula generation

        with NMR spectroscopy.  The updated Bruker Fusion-SV 1.1 solution now

        includes additional 2D NMR methods for even higher confidence in rapid,

        automated structure verification.  Designed for the workflow of

        medicinal and synthetic chemists in pharma, chemical industry or in

        academia, Bruker Fusion-SV 1.1 guides chemists to meaningful results

        with minimal interactions and without the need for expert knowledge.

    --  InsightMR: Designed for the optimization of chemical reactions under

        process conditions, the new InsightMR™ solution uses on-line NMR

        monitoring to enhance process understanding.  InsightMR has a new flow

        unit with temperature-controlled transfer lines to enable fast and

        continuous transfer of reaction mixtures from a vessel to the

        spectrometer.  InsightMR software features a user-friendly interface to

        allow both expert and non-expert NMR users to set up experiments in

        deuterated and non-deuterated solvents and optimize acquisition

        parameters on-the-fly, based on real-time kinetic data.

    --  Fourier 300 HD: In 2010, Bruker introduced its successful entry-level

        NMR system, the Fourier 300.  Based on the positive customer response,

        we now introduce an improved version, the Fourier 300 HD.  Derived from

        our renowned Avance III HD electronics, the Fourier 300 HD provides an

        entry level, two-channel system for proton and carbon operation for

        budget-conscious customers.  The system is equal in specifications to

        our Avance series and is operated by TopSpin software.  With its small

        footprint and freely available TopSpin Processing software (limited to

        academic users), the Fourier 300 HD is an excellent system for education

        and smaller routine labs. 

Werner E. Maas, Ph.D., President of the Bruker BioSpin MRS Division, commented:  "In addition to developing high field magnets, such as our new Aeon 1 GHz magnet, and new, highly sensitive X-nucleus direct detection CryoProbes, we also focus our RD on tools that make our customers successful by enhancing their productivity or expanding their range of NMR applications.  In addition to introductions for sample handling and data analysis, we started the Intelligent NMR Spectrometer Initiative, a multi-year program to enhance productivity and ease-of-use of our spectrometers. SmartDriveNMR and lab2NMR are just two of the early results of this program."

About Bruker Corporation

For more than 50 years, Bruker has enabled scientists to make breakthrough discoveries and develop new applications that improve the quality of human life.  Bruker's high-performance scientific research instruments and high-value analytical solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels.

In close cooperation with our customers, Bruker is enabling innovation, productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy, nano-analysis and industrial applications, as well as in cell biology, preclinical imaging, clinical research, microbiology and molecular diagnostics.  For more information, please visit

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Bruker Corporation


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