Bosch Presents Highlights from Processing, Inspection, and Isolator Technology


Equipment for solid and liquid pharmaceuticals

· Tablets: mixing, granulating, pressing and coating on a laboratory scale

· Compact inspection unit KKX 3900 for capsules

· Fast Air Lock ISS 100: quick transfer into and out of isolators

At TechnoPharm 2013 in Nuremberg, Germany (hall 6, booth 235), Bosch Packaging Technology presents highlights from its comprehensive pharmaceutical portfolio. The laboratory devices Solidlab 1 and 2, the Manesty tablet press Xpress 100, and the smallest high-shear mixer granulator Hüttlin Mycromix represent the process technology section.

Novelties in inspection technology include the KKX 3900 inspection unit for filled capsules and the table-top device ETAC Easy View for visual inspection of containers filled with liquid pharmaceuticals. Bosch's trade show appearance is rounded out by the Fast Air Lock ISS 1000 for quick transfer of pharmaceutical equipment into and out of isolators.

Laboratory devices for small batches

Since 2011, the product brands Hüttlin and Manesty are part of Bosch Packaging Technology's portfolio. The two process technology specialists have jointly developed the laboratory machines Solidlab 1 and 2 for the manufacture of tablets and pellets. By using a common base assembly, the three process modules powder mixing, granulating and coating are combined in one single machine, enabling cost and space optimization.

Solidlab 1 handles batches from 0.05 to two kilograms. Based on the same construction principle, Solidlab 2 processes volumes from 0.5 to 12 kilograms.

Hüttlin Mycromix is the smallest high-shear mixer granulator in the laboratory equipment range. It handles batches from 0.05 to one kilogram.

The bottom drive unit Hüttlin Gentlewing ensures highly homogenous mixing qualities for granulates. All processes can be easily transferred to production equipment via scale-up. The tablet press Manesty Xpress 100 is equally suited for research and development purposes. Its data acquisition system provides an ideal platform for evaluation of new tableting formulations. With a range of flexible turret options, clinical trial batches can also be produced. On the Xpress 100 the same mpower-software is used as on production machines, enabling easier comparison of test results.

Pioneers in inspection and isolator technology

The inspection unit KKX 3900 is used for weight and quality control of filled hard capsules. It can be installed after any capsule filling machine and achieves an output of up to 220,000 capsules per hour. The system is based on soft x-ray technology and inspects quality parameters such as weight and length of capsules with high accuracy. Apart from the 100 percent inline weight control, the digital image evaluation gathers further process-relevant information.

The inspection technology portfolio from Eisai Machinery includes manual, semi- and fully-automated systems. The computer-bound visual inspection unit ETAC Easy View, for instance, examines vials, ampoules, syringes and cartridges for particle contamination and cosmetic container defects and is designed for containers with diameters from 8 to 50 millimetres. A camera transmits the results directly to the All-in-One computer, which allows for an especially fast evaluation. Due to its compact design, the userindependent and fully validatable table-top device is flexibly applicable.

The Fast Air Lock ISS 1000 was developed for transferring pharmaceutical equipment into and out of isolators. An efficient evaporation process and an optimized loading unit result in very fast cycle times of only approximately 20 minutes. The ISS 1000 is available as integrated or stand alone module and operates independently from the main filling isolator.

Contact person for press inquiries:

Inga Strobel

Christin Poenisch

phone: +49 7951 402-648

phone: +49 711 811-58502

Based in Waiblingen near Stuttgart, Germany, and employing 4,700 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact. Additional information is available online at www.boschpackaging.com. The Bosch Group is a leading global supplier of technology and services, active in the fields of automotive technology, energy and building technology, industrial technology, and consumer goods. According to preliminary figures, more than 306,000 associates generated sales of 52.3 billion euros in 2012. The Bosch Group comprises Robert Bosch GmbH and its more than 350 subsidiaries and regional companies in some 60 countries. If its sales and service partners are included, then Bosch is represented in roughly 150 countries. This worldwide development, manufacturing, and sales network is the foundation for further growth. Bosch spent some 4.5 billion euros for research and development in 2012, and applied for over 4,700 patents worldwide. The Bosch Group's products and services are designed to fascinate, and to improve the quality of life by providing solutions which are both innovative and beneficial. In this way, the company offers technology worldwide that is "Invented for life."

The company was set up in Stuttgart in 1886 by Robert Bosch (1861-1942) as "Workshop for Precision Mechanics and Electrical Engineering." The special ownership structure of Robert Bosch GmbH guarantees the entrepreneurial freedom of the Bosch Group, making it possible for the company to plan over the long term and to undertake significant up-front investments in the safeguarding of its future. Ninety-two percent of the share capital of Robert Bosch GmbH is held by Robert Bosch Stiftung GmbH, a charitable foundation. The majority of voting rights are held by Robert Bosch Industrietreuhand KG, an industrial trust. The entrepreneurial ownership functions are carried out by the trust. The remaining shares are held by the Bosch family and by Robert Bosch GmbH.

Additional information is available online at www.bosch.com and www.bosch-press.com.

Robert Bosch GmbH

Postfach 10 60 50

D-70049 Stuttgart

E-mail christin.poenisch@bosch.com

Phone +49 711 811-58502

Fax +49 711 811-58509

Corporate Communications,

Brand Management, and Sustainability

Senior Vice President:

Uta-Micaela Dürig

www.bosch-press.com

February 2013

PI 8007 PA cp

Press release

TechnoPharm 2013

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