Analysis System performs antisense and antigene studies.

Press Release Summary:




Thermalmelt Tm Analysis System, for use with company's UV-Vis spectrophotometers, monitors nucleic acid dissociation as temperature is raised. It measures absorbance changes at specified wavelengths and determines melting temperature at which half of double stranded form separates. Thermodynamic parameters obtained enable prediction of thermal stability and structure of nucleic acids. Instrument measures up to 8 samples with path lengths from 1-10 mm.



Original Press Release:



Thermalmelt Analysis System For Antisense, Antigene, And Hybridization Studies



Shimadzu Scientific Instruments has introduced a Tm Analysis System for use with their extensive line of UV-Vis spectrophotometers. Designed to monitor nucleic acid dissociation as temperature is raised, the Tm Analysis System measures absorbance changes at user specified wavelengths and determines the melting temperature at which half of the double stranded form separates. The thermodynamic parameters obtained enables the prediction of thermal stability and structure of nucleic acids, target validation by antisense and antigene methods as well as the analysis and optimization of a variety of techniques based on hybridization phenomena.

Capable of simultaneous measurement of up to 8 samples with path lengths from 1 mm to 10 mm, the Shimadzu Tm Analysis System allows parallel analysis as well as high throughout screening of sequences. Temperature control ranges from .0°C to 10°C with 12 step rate change of 0.1°C to 5.0°C per minute. Easy to operate dedicated 32-bit software for Windows(R) enables parameter setup, real-time monitoring, Tm analysis, and output to be performed seamlessly. The software supports a variety of functions including multi-wavelength measurement, multi-step temperature programming, and continuous/step temperature scanning.

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