Third German Business Innovation Award for Leica Microsystems

Frankfurt/Main. By winning its third German Business Innovation Award, Leica Microsystems has
ultimately established its position at the cutting edge of German innovators. On January 21st,
President Dr. Wolf-Otto Reuter and Dr. Thomas Zapf, Director Scientific Relations, received the award
in Frankfurt. The high-tech optical company wins the award in the medium-sized business category.
The company already won the prestigious award in 1984 for the ELSAM acoustic microscope and
again in 2002 for the DUV high-resolution microscope objective for photomask and wafer fabrication.

This time, the jury conferred the award for a highresolution
microscope with 4Pi technology: the Leica
TCS 4PI. With this microscope, submicroscopically
small structures in living cells and cell organelles can
be imaged in 3D with clearer detail and more
structural information than any other light microscope
on the market. It provides basic research with a tool to
find out new information on protein-based diseases.
According to Zapf, it opens up completely new
horizons for the diagnosis and therapy of malaria,
Alzheimer's or AIDS, for example.

4Pi technology, which overcomes all the former barriers of light microscopy, was invented by
Prof. Stefan Hell, Director of the Max Planck Institute of Biophysical Chemistry, and developed for the
market by Leica Microsystems. The object of investigation is enclosed by two high-quality objectives
arranged opposite each other. This means that the object can be observed with a practically complete
spherical wave. This principle gives the microscope its name "4PI" - with reference to the full solid
angle. Applied to fluorescence microscopy, this leads to a 3 to 7 times narrower focus along the
microscope axis. The result is a resolution of under 100 nanometers, a dimension where key life
processes take place.

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"We are proud to have won the Innovation Award of German Industry for the third time with the world's
highest-resolution commercial fluorescence microscope, again demonstrating Leica Microsystems'
innovation potential," said Reuter. "While we are naturally delighted to receive the award in recognition
of our achievements, we are equally encouraged to see the progress that our customers are making in
their research with our innovation." The microscope is being used at the universities of Heidelberg,
Hanover, Muenster and Ulm as well as in the USA, UK, Spain and the Netherlands.
Dr. Reuter is available for individual telephone calls until 1 p.m. today. Please book in advance with:
Dr. Kirstin Henze,, Tel.: +49/(0)6441/292550.

Leica Microsystems is a leading global designer and producer of innovative high-tech precision optics
systems for the analysis of microstructures. It is one of the market leaders in each of the fields
Microscopy, Confocal Laser Scanning Microscopy, Imaging Systems, Specimen Preparation and
Medical Equipment. The company manufactures a broad range of products for numerous applications
requiring microscopic imaging, measurement and analysis. The company offers system solutions in
the areas of Life Science including biotechnology and medicine, as well as the science of raw
materials and industrial quality assurance. The company is represented in over 100 countries with 8
manufacturing facilities in 6 countries, sales and service organizations in 19 countries and an
international network of dealers. With its workforce of about 3,700 employees it made a turnover of
530m euros in 2004 (including the Semiconductor Division which was divested in September). The
international management is headquartered in Wetzlar, Germany.

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