Oystar Hüttlin Provides Pharmaceutical Leader Sanofi Aventis with State-of-the-Art Manufacturing Tools

EDISON, NJ - The OYSTAR USA Process and Packaging Technology Division, through its Hüttlin division, supports the efforts of Sanofi Aventis, one of the world's leading pharmaceutical companies, to manufacture Doliprane®. Doliprane® is a leading brand of Acetaminophen tablets, a medication widely used in most of Europe for pain and fever reduction.

In Cologne, Germany the OYSTAR Hüttlin HTG 1800 and HD 600 units produced granulates for a total of 359 million effervescent tablets for the French market in 2009. This rate of production is made possible through the installation of a fully integrated granulating line. No manual operations of any kind are necessary - from dust-free loading via big bags to filling the respective container. The HTG 1800 high-shear mixer granulator and the HD 600 fluidized bed system are equipped with pneumatic filling mechanisms, including integrated weighing, pneumatic empty mechanisms as well as pneumatic transfer between the mixer and fluidized bed, thus providing for a completely closed production process. The complete plant has a shockproof design and satisfies the highest safety requirements.

In Lisieux, France, Sanofi Aventis had the fully automated HDGC 1200 fluidized bed granulation system from OYSTAR Hüttlin installed with an upstream big bag unloading station. The apparatus carries out two process steps: spray granulation and the drying process in a single product container. The initial output makes the production of granulates possible for more than 500 million Acetaminophen tablets per year. Just like in Cologne, an efficient cleaning concept is provided to prevent cross-contamination. Thus each of the plants is automatically cleaned and dried overnight via the WIP system ("Washing in Place"), from the loading station to discharge, so that products can be manufactured on the following morning with the highest degree of purity.

About OYSTAR Hüttlin

Hüttlin GmbH, based in Schopfheim (Baden-Württemberg), is a global player and member of the OYSTAR group of companies. The enterprise is one of the leading manufacturers of process equipment for the drying, granulation and coating of fine particles. Its portfolio focuses on the pharmaceutical industry. With its Pharma Service center of competence, OYSTAR Hüttlin offers a broad range of dedicated services including testing, formulation support, support for scale-up and product transfer, in-house and on-site training, and production systems troubleshooting. oystar.huettlin.de

About OYSTAR Group

OYSTAR - The Process & Packaging Group is one of the world's leading suppliers of packaging machinery, technology and services. OYSTAR has extensive process know-how in the key industries of dairy products, food and consumer, as well as pharmaceuticals and cosmetics. Based in Stutensee near Karlsruhe, the holding company currently represents 14 manufacturing companies as well as numerous sales and service companies. At present OYSTAR Holding employs a workforce of approximately 2,300 worldwide and generated a total of EUR 402 million in sales in 2009.

The OYSTAR USA Pharmaceutical Packaging Division is based in Edison, NJ. For more information please call 732.343.7600 or visit the web site at www.oystarusa.com.

Alysa McKenna

Turchette Advertising

973.227.8080, ext. 29


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