International Symposium for Sterile Filling by Bosch

• Independent platform for knowledge and experience exchange

• Keynote speaker: Prof. Dr. Dr. Franz-Josef Radermacher

• Exhibition of product innovations in pharmaceutical technology

Crailsheim - On May 14 and 15, 2013, Bosch Packaging Technology held its 7th “Crailsheimer Pharmatag”. The international symposium for sterile filling offered pharmaceutical experts and opinion leaders an independent platform for interdisciplinary knowledge and experience exchange. “We spent two successful and exciting days with guests from all over the world. With its extensive program and interesting topics, the Crailsheimer Pharmatag once again was the perfect event to discuss current trends with colleagues from the industry,” said Joachim Brenner, site manager in Crailsheim. With a facility tour on the first day, the approximately 250 visitors had the opportunity to look behind the scenes and to celebrate the inauguration of the new assembly hall. Day one ended with an entertaining dinner event for all participants.

Field reports and expert discussions

The second day traditionally focused on presentations and panel discussions. Bosch was delighted to introduce Prof. Dr. Dr. Franz Josef Radermacher, head of the Research Institute for Applied Knowledge Processing in Ulm, as keynote speaker. He opened the morning session with his lecture on current and future pharmaceutical trends. During the following presentations, the audience learned about the role of research and development in the pharmaceutical manufacturing process, and new challenges in aseptic filling. Speakers included representatives of Boehringer Ingelheim, Ypsomed, AbbVie, Lilly, Sartorius Stedim Biotech, and the Fraunhofer Institute in Braunschweig.

Panel discussion and product highlights

Friedbert Klefenz, president of Bosch Packaging Technology, and Joachim Brenner, site manager in Crailsheim, discussed current production trends such as contract manufacturing, small batch sizes, ready-to-use containers, 100 percent in-process control and lean production with participants. Charlotte Enghave Fruergaard, PhD, from NNE Pharmaplan, led through the program. A further highlight of this year’s Pharmatag was the presentation of new products from Bosch. Participants gained insights into the entire product portfolio of process and packaging technology for solid and liquid pharmaceuticals.

The new filling and closing machine MLF 5088 was particularly highlighted among the exhibits. It offers an output of up to 400 vials per minute with integrated 100 percent in-process control (IPC). The combined filling station with eight dosing heads is suited for restricted access barrier systems (RABS) as well as isolators, and containment systems for toxic products.

System competence for solid and liquid pharmaceuticals

With the integration of Eisai Machinery, Bosch has substantially extended its inspection portfolio. The semi-automatic VIS 200 is used for the inspection of empty and filled vials from two to 200 milliliters. It examines containers for foreign particles in liquid or lyophilized pharmaceuticals, as well as cosmetic defects such as glass cracks or missing caps. Furthermore, Bosch has developed the KKX 3900, a new inspection unit for capsules based on soft x-ray technology.

Bosch also showcased the Fast Air Lock ISS 1000 for fast and contamination-free transfer of pharmaceutical equipment into and out of isolators, and the standardized CIP/SIP (cleaning and sterilization in place) compact unit for pharmaceutical containers, vessels and small production accessories. The laboratory machine Solidlab 2 combines three process modules in one single machine: powder mixing, granulating and coating of pharmaceutical pellets and tablets. The exhibition was rounded out by a comprehensive range of services, including the new mobile conference system Mavus, and a mobile data collection system for the evaluation of Overall Equipment Effectiveness (OEE).

Based in Waiblingen near Stuttgart, Germany, and employing 5,000 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact. Additional information is available online at

The Bosch Group is a leading global supplier of technology and services. In fiscal 2012, its roughly 306,000 associates generated sales of 52.5 billion euros. Since the beginning of 2013, its operations have been divided into four business sectors: Automotive Technology, Industrial Technology, Consumer Goods, and Energy and Building Technology. The Bosch Group comprises Robert Bosch GmbH and its roughly 360 subsidiaries and regional companies in some 50 countries. If its sales and service partners are included, then Bosch is represented in roughly 150 countries. This worldwide development, manufacturing, and sales network is the foundation for further growth. Bosch spent some 4.8 billion euros for research and development in 2012, and applied for nearly 4,800 patents worldwide. The Bosch Group’s products and services are designed to fascinate, and to improve the quality of life by providing solutions which are both innovative and beneficial. In this way, the company offers technology worldwide that is “Invented for life.”

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