Screening Data Analysis Software supports cloud collaboration.
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Press Release Summary:
As single-platform screening data analysis system with built-in business logic for standardizing and automating screening workflows, Genedata Screener® v11 supports compound combination screens to analyze compound synergy effects as well as high-throughput flow cytometry – including cell sub-population analysis. Solution supports High-, Medium-, and Low-Throughput Screens, HCS, Ion Channel Screening, Label-free (including thermal shift), and other assay technologies.
Original Press Release:
Genedata Screener 11 with Compound Combination Screening and Collaboration in the Cloud Announced at Bio-IT World 2013
With the industry's broadest technology support, Genedata Screener removes analysis bottlenecks in large-scale cell biology experiments
Boston, Mass. -- Genedata, a leading provider of advanced software solutions for drug discovery and life science research, today announced the release of Genedata Screener® 11, a single-platform screening data analysis system with built-in business logic for standardizing and automating screening workflows. The new Genedata Screener now supports compound combination screens to analyze compound synergy effects as well as high throughput flow cytometry including cell sub-population analysis. Integrating with any plate-based instrument, Genedata Screener supports High, Medium and Low Throughput Screens, High Content Screening (HCS), Ion Channel Screening, Label-free (including thermal shift), and other assay technologies. Now, it also can be used in the cloud to enable pharma-CRO collaboration on the same analysis platform. Genedata Screener 11 will be demonstrated at the Bio-IT World Conference & Expo (World Trade Center; Booth #228; April 9-11).
Realizing the Promise of Compound Combination Screening
Compound Combination Screening holds the promise of lowering costs for drug discovery while delivering significantly improved drug therapies for illnesses such as cancer, diabetes, and infectious diseases. Today's instrumentation enables high-throughput Compound Combination Screening experiments measuring, for example, 200 or more combinations across several cell lines. Data analysis, however, for combination experiments remains a major bottleneck as the specifics of combination screening are not fully supported by current screening data analysis systems. The Genedata Screener Compound Synergy Extension removes this bottleneck to enable full realization of the experimental capacity. Compound Synergy Extension can easily be added to an existing Genedata Screener installation, which:
• Eliminates manual data processing of compound synergy data
• Imports information for multiple compounds per well from files or database systems
• Fits mono-therapeutic Dose Response Curves
• Calculates Synergy Scores using the Loewe and Highest Single Agent models
• Visualizes combination effects in heat maps (e.g. for measured, modeled and excess activity)
New Applications for Single-Cell Analysis
Genedata Screener 11 also features an enhanced Cell Population Extension for improved support of high throughput flow cytometry, cell cycle and similar experiments that define and display cell sub-populations. In a single view, researchers can define, manage, and display cell sub-populations and use cell sub-populations as input for cell-to-well data aggregation. These capabilities streamline processing of cell-based experiments and enable corporate-wide management of single-cell data, at an unprecedented scale.
Collaboration in the Cloud
Enabling new levels of collaborative research and screening data analysis, Genedata Screener 11 features advanced support for encrypted data transmission and authentication. Fully cloud-compliant, Genedata Screener 11Â standardizes data analysis across different organizations and multiple sites. With the Genedata Screener server in the cloud, users run their clients in the local environment: while data transfer to and from the cloud is determined by the bandwidth of the network connection, Genedata Screener data processing speed and unique interactive capabilities persist.
"Genedata Screener 11 will unleash new opportunities in lead optimization and target validation by giving pharmaceutical and biotechnology researchers a standardized platform on which they can efficiently visualize and explore compound combinations at unprecedented processing speed and with unsurpassed result quality," said Dr. Othmar Pfannes, CEO of Genedata. "The ongoing innovation we are able to consistently deliver with each version of Genedata Screener is a result of our partnerships with industry leaders and our significant investments in and commitment to Genedata R&D."
About Genedata
Genedata transforms data into intelligence with a portfolio of advanced software solutions for drug discovery, industrial biotechnology, and life science research. Used by a majority of the world's top 50 pharmaceutical companies and leading research organizations, Genedata solutions make research data accessible and understandable, enabling scientific discovery that fights disease and improves health and quality of life worldwide. Founded in 1997, Genedata is headquartered in Switzerland, and has offices in Japan, Germany, and the US. www.genedata.com
Contacts
Allison Kurz
Genedata
Marketing & Communications
Phone: +41 61 511 8459
communications@genedata.com
Jackie Thrasivoulos
Genedata
Public Relations
Phone: +1 508 881 3109
jackie.thrasivoulos@genedata.com
All product and service names mentioned are the trademarks of their respective companies.
Genedata AG - Margarethenstrasse 38, 4053 Basel, Switzerland - Tel. +41 61 511 8400 - Fax +41 61 511 8484
Genedata Inc. - 750 Marrett Road, One Cranberry Hill, Suite 403, Lexington, MA 02421 - Tel. +1 781 357 4755 - Fax +1 781 357 4770
Genedata Inc. - 109 Stevenson Street, 4th Floor, San Francisco, CA 94105 - Tel. +1 877 436 3872 - Fax +1 415 970 6631
Genedata GmbH - Lena-Christ-Strasse 50, 82152 Martinsried, Germany - Tel. +49 89 4581 9010 - Fax +49 89 4581 9015
Genedata KK - 1-7-11, Higashi-Gotanda, Shinagawa-Ku, Tokyo 141-0022, Japan - Tel. +81 3 6721 7261 - Fax +81 3 6721 7262
www.genedata.com - communications@genedata.com
