MALS Instrument facilitates macromolecular characterization.October 5, 2007 -
Calypso automated protein association and aggregation system enables quantitative, nondestructive characterization of protein-protein interactions in native solution using Composition-Gradient MALS (CG-MALS). It consists of hardware and dedicated software for automating CG-MALS measurements as well as Zimm plots and dn/dc determinations. Computer-controlled syringe pumps automate sample mixing, dilution, and delivery, while software controls experiment, acquires data, and analyzes results.
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Original Press release
Wyatt Technology
6300 Hollister Ave.
Santa Barbara, CA, 93117
USA
Wyatt Technology Launches Its New Calypso Automated Protein Association and Aggregation System
SANTA BARBARA, CALIFORNIA (September 24, 2007) - Wyatt Technology Inc., the world leader in absolute macromolecular characterization, announces the launch of its new Calypso automated protein association and aggregation system. This instrument package enables the rapid, quantitative, nondestructive characterization of protein-protein interactions in native solution using Composition-Gradient Multi-Angle Light Scattering (CG-MALS).
Interactions between proteins are at the heart of many biological functions and are of great importance for every process in a living cell. Information about how proteins such as enzymes and inhibitors interact, improves our understanding of diseases and can point to new therapeutic approaches. Characterization of protein aggregation is critical to the pharmaceutical and biotechnology industries, where it is particularly important that the protein is in the solution phase in specific formulation buffers. There are numerous methods for detecting protein interactions and aggregation kinetics, each varying in sensitivity and specificity. CG-MALS is an ideal means for measuring the proteins in their native solution:, protein samples need not be tagged, immobilized on a surface, or otherwise modified from their natural state. It is a sensitive and precise method for the measurement of complexes and aggregates through the absolute determination of molar mass and can non-destructively characterize both weak and strong interactions. Simple or complex association stoichiometries may be analyzed, providing equilibrium dissociation constants from picomolars to millimolars, as well as self- and cross- viral coefficients and aggregation or association kinetics.
The Wyatt Calypso system consists of hardware and dedicated software for automating CG-MALS measurements as well as Zimm plots and dn/dc determinations. Computer-controlled syringe pumps automate the sample mixing, dilution and delivery, while intuitive software controls the experiment, acquires data and analyzes the results. The system can also be used to facilitate the study of the composition dependence of any measurable solution property (spectroscopic, hydrodynamic, calorimetric).
For more information on Wyatt Technology's MALS instruments please visit www.wyatt.com or e-mail info@wyatt.com
About Wyatt
Based in Santa Barbara, California, Wyatt Technology is the world's leading provider of instruments for absolute macromolecular characterization. With over 40 years' experience developing multi-angle light scattering detectors, working with customers in the biotechnology, chemical, petrochemical, pharmaceutical, academic and government arenas, Wyatt prides itself on its entrepreneurial spirit, and the uniqueness of its offerings. The Company's groundbreaking technology and uncompromising levels of customer care make Wyatt the global hallmark in its field. For more information, please visit www.wyatt.com
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