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Hardware/Software Interface connects light and SEMs.

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Hardware/Software Interface  connects light and SEMs.
Hardware/Software Interface connects light and SEMs.
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November 15, 2010 - Comprising transferable specimen holder and software module, Shuttle and Find Interface for correlative light and electron microscopy enables users to recall regions of interest in fixed specimens in electron microscope that were previously identified in light microscope and vice versa. Process allows for rapid and precise overlay of light and electron microscope images, high-resolution magnification of details, and merger of functional and structural information.

Carl Zeiss Introduces Correlative Light and Electron Microscopy Solution for Life Sciences

(Archive News Story - Products mentioned in this Archive News Story may or may not be available from the manufacturer.)

Carl Zeiss Microimaging, Inc.
One Zeiss Dr.
Thornwood, NY, 10594-1939

Press release date: November 12, 2010

Integrated hardware/software interface enables productive workflow between light and electron microscopes for the first time

Thornwood, NY - Carl Zeiss introduces a unique hardware/software interface to connect light and scanning electron microscopes for correlative microscopy in the life sciences. This "Shuttle & Find" interface for correlative light and electron microscopy (CLEM) enables users to recall regions of interest in fixed specimens in an electron microscope that were previously identified in a light microscope, and vice versa. The entire process takes only a few seconds and opens new dimensions in microscopy, allowing for rapid and precise overlay of light and electron microscope images, high-resolution magnification of the details, and the merger of functional and structural information.

The key elements of Shuttle & Find for CLEM are, respectively, a transferable specimen holder that enables smooth specimen transfer between the light and electron microscopes (shuttle) and a software module that controls all the functions of light and electron microscopes needed to identify and recall the defined region of interest (find). Dr. Ulrich Simon, president and CEO of Carl Zeiss MicroImaging GmbH says, "After the successful launch of Shuttle & Find for materials analysis, we are taking the next step and providing scientists in life science disciplines with a productive solution for correlative microscopy. As the world's only provider of both light and electron microscopes in all performance classes, Carl Zeiss is uniquely well suited to bridge the micro and nano worlds."

In the life sciences, the relationship between structure and function is increasingly becoming a focal point of interest. Correlative examinations that combine fluorescence microscope images and scanning electron microscope images of the same region open up new and fascinating possibilities. One scientific partner in the development of the interface is Dr. Roger Wepf, director of the EMEZ Electron Microscope Center at the ETH in Zurich. Dr. Wepf called the interface "very helpful indeed. Shuttle & Find eliminates the time-consuming search for identical regions in the light and electron microscopes. Correlative microscopy now really works even if there are still some issues regarding specimen preparation."

Shuttle & Find connects all light microscopes from Carl Zeiss that can be equipped with a motorized stage (SteREO Discovery, Axio Scope, Axio Imager, Axio Examiner and also the Axio Observer inverted microscope) with all ZEISS scanning electron microscopes of the types EVO, SIGMA, SUPRA, ULTRA and MERLIN, as well as with the CrossBeam (FIB-SEM) system AURIGA.

About Carl Zeiss
Carl Zeiss MicroImaging, Inc., a subsidiary of Carl Zeiss, Inc., offers microscopy solutions and systems for research, laboratories, routine and industrial applications. In addition, Carl Zeiss MicroImaging markets microscopy and digital pathology systems for the clinical market, as well as spectral sensors for industrial and pharmaceutical applications. Since1846, Carl Zeiss has remained committed to enabling science and technology to go beyond what man can see. Today, Carl Zeiss is a global leader in the optical and opto-electronic industries.

With 11,249 current employees in the Group and offices in over 30 countries, Carl Zeiss is represented in more than 100 countries with production centers in Europe, North America, Central America and Asia. For more information on the breadth of solutions offered by Carl Zeiss MicroImaging, please visit

Attention publishers: Please forward all Sales Inquiries to: Karin A. Salerno,
Marketing Communications Manager
Phone: (914) 681-7627 ; E-mail:
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