Data Analysis Software aids DNA copy number analysis.April 17, 2009 -
Used for DNA copy number analysis of microarray-derived data, platform-independent Nexus Copy Number v4 provides algorithm for SNP arrays. It combines log ratio and B-allele frequency values to segment genome, detection of loss of hetrozygosity (LOH), and allelic imbalance calls for SNP array data, along with predictive power analysis for continuous data types, query tool for listing genomic events for multiple genes/regions, and one-click data loading tool.
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Original Press release
BioDiscovery, Inc.
2121 Rosecrans Ave., Suite 3315
El Segundo, CA, 90245
USA
BioDiscovery Releases Nexus Copy Number Version 4 for DNA Copy Number Analysis and Visualization
EL SEGUNDO, CA, April 1, 2009 - BioDiscovery, Inc. the pioneering developer of integrated software solutions for microarray-based research, announced today the release of Nexus Copy Number Version 4, a platform independent and efficient application for DNA copy number analysis of microarray derived data. This latest version of the popular Nexus Copy Number software offers many new and unique features including a new algorithm for SNP arrays that combines log ratio and B-allele frequency values to segment the genome, detection of loss of hetrozygosity (LOH) and allelic imbalance calls for SNP array data, predictive power analysis for continuous data types, a query tool for listing genomic events for multiple genes or regions, and a one-click data loading tool.
"With version 4, we have continued our push at maintaining Nexus Copy Number as the premier tool for genomic aberration analysis with the most sophisticated analysis and visualization capabilities regardless of the platform. One of the main new features allows Nexus to take advantage of B-allele frequency values from SNP array data to both improve segmentation results as well as report allelic events, such as LOH, Allelic Imbalance, and Copy Neutral LOH." said Dr. Soheil Shams, CSO of BioDiscovery, Inc. "We are quite proud of the recognition that Nexus Copy Number has received in the market by being adopted as the primary tool at most of the renowned research and clinical laboratories across the globe."
Nexus Copy Number can integrate and process together, in a single project, data from commercial array platforms such as Agilent, Affymetrix, Illumina, Roche NimbleGen, as well as custom arrays. The software is applicable to many flavors of studies from focused projects of a cytogeneticist to large scale cancer studies. BioDiscovery is attuned to such different needs and offers Nexus Copy Number in two editions: Standard and Discovery.
The Standard Edition has all necessary tools for copy number analysis of CGH and SNP arrays including customizable reports listing aberrant regions and copy number and allele event calls, minimum regions of aberration among a set of samples, individual sample results, and includes a genomic browser with customizable annotation tracks for such items as genes, CNVs, exons, probes, and genetics diseases/disorders, and project-wise gene and region based queries.
The Discovery Edition adds features which aid in exploration of data for more research based use. These include clustering based on similar aberration profiles, identification of statistically different regions of change between sample sub-groups, gene ontology enrichment analysis, survival analysis and integration of external data such as gene expression.
About BioDiscovery, Inc.
BioDiscovery is a leader in the development of microarray advanced bioinformatics software and services that enable its customers to revolutionize drug discovery and diagnostics by efficiently managing, integrating, and analyzing data generated using high-throughput microarray technology. Contact BioDiscovery: 310-414-8100 or www.biodiscovery.com
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