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Original Press Release

Hot Water Cascade System for Sterilzation

Press release date: June 5, 2014

The hot water cascade system developed by MMM MnchenerMedizinMechanik GmbH enables liquids in closed receptacles made of glass or other temperature-resistant materials (such as ampoules) to be sterilized quickly, reliably and gently. This plays a major role in pharmaceutical/biotechnology production.

GEM valves are used to regulate the filling of the sterilization chamber during the process. This is first filled up to a defined level with deionised sterilization water. This water then circulates through a steam-heated heat exchanger and cascades over the item being sterilized at a continuously rising temperature of up to 121 C. In the subsequent cooling phase, the sterilization water flows through the now water-cooled heat exchanger and cools the item being sterilized down to a specific temperature.

GEM 554 angle seat globe valve and GEM 490 butterfly valve in equipment room

Pneumatically actuated GEM 554 globe valves control the filling of the sterilization chamber with water and the way in which the heat exchanger is heated by steam and cooled using water. By contrast, GEM 490 butterfly valves are used in the circulation line, as these have significantly more compact installation dimensions yet very high flow rates in comparison with pneumatically operated angle seat globe valves of the same nominal diameter. Furthermore, to meet these stringent requirements, they are fitted with highly resistant TFM™ plastic and FDA-approved silicone as a sealing material.

Background information
GEM is one of the world's leading manufacturers of valves, measurement and control systems. Over the course of 50 years, this globally focused, independent family owned enterprise has established itself in important industrial sectors thanks to its innovative products and customised solutions for process media control. GEM is the world market leader for sterile valve applications in the pharmaceutical industry and biotechnology industries.

Today, the GEM Group employs over 800 employees in Germany and more than 1400 worldwide. Manufacturing is carried out at six manufacturing sites in Germany, Switzerland, China, Brazil, France and the USA. From Germany we coordinate global marketing with 24 subsidiaries and with a large distributor network in 53 markets, the GEM Group is active on all five continents. GEM will continue to establish itself in future markets with its international growth strategy. To achieve this, GEM has opened a new Production and Logistics Centre in 2013.

A broad based modular system and adapted automation components mean that predefined standard products and customised solutions can be combined to make over 400,000 product versions.
Further information can be found at

Corporate Communication
Eva Zink
Tel.: +49 (0) 7940 123-708
Fax.: -49 (0) 7940 123-487

GEM Gebr. Mller Apparatebau GmbH & Co. KG
Fritz-Mller-Str. 6-8
74653 Ingelfingen
Germany Page 1 von 2
Tel.: -49 (0) 7940 123-0
Fax: -49 (0) 7940 123-192


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