Bosch Packaging Technology: Extensive Line Competence
Eleven launches on one booth
• Exemplary line concepts for different therapeutic areas
• Development, production, filling and packaging of solid and liquid pharmaceuticals tailored to customer needs
• Comprehensive consulting and services before, during and after start-up
Frankfurt/Main, Germany – At Achema 2015, Bosch Packaging Technology, a leading supplier of process and packaging technology, focuses on its line competence. Trade show visitors can expect eleven market launches for the pharmaceutical and biopharmaceutical industries on a floor space of over 1,000 square meters. With a combination of exhibits and multimedia presentations, Bosch showcases exemplary line configurations for different therapeutic areas. "Whether customers need a complete line for the production and packaging of oncology drugs, for treatment of diabetes or gastric ulcers, or a solution for eye drops or cough syrup – Bosch is the competent partner for all pharmaceutical requirements," explains Christian Treitel, head of pharma business development at Bosch Packaging Technology.
Exemplary lines for solid and liquid pharmaceuticals
Bosch presents line configuration examples for the manufacturing of tablets for diabetes treatment, as well as for capsules that are administered to cure gastric and intestinal ulcers. The new Hüttlin granulation line Granulean, which is available in three standardized sizes, can for instance be connected to the new Manesty TPR tablet presses via suitable handling and transfer equipment. The capsule line comprises precise dosing, amongst others of pellets, as well as filling on the new GKF 2600 capsule filling machine, followed by inspection and transfer to the packaging process.
On the basis of different therapeutic areas and packaging types, three exemplary lines for liquid pharmaceuticals further illustrate Bosch's line competence. For instance, equipment for all process steps of oncology drugs administered in vials is available: from Pharmatec bioprocess systems to highly precise filling, integration of freeze-drying and capping to external cleaning of vials with the new RAN washing machine. Apart from particle and cosmetic inspection, Bosch also presents a new inspection machine for leak detection. Furthermore, Bosch offers cartoning machines with sophisticated serialization and aggregation solutions for the secondary packaging process.
New developments based on pharmaceutical requirements
An exemplary syringe line shows how customers can efficiently produce, fill and package their drugs for the treatment of autoimmune disorders. Process systems for the production of active pharmaceutical ingredients and a new system for the generation of WFI (water for injection) are followed by formulation and filling on the flexible platform for pre-sterilized syringes with single-use filling systems. The latter can be combined with barrier systems and further equipment such as the new wireless glove tester. The line is complemented by particle and cosmetic inspection, further downstream equipment and complete secondary packaging solutions.
The manufacturing and filling process of liquid pharmaceuticals into cartridges is illustrated by the therapeutic area of diabetes care. The line starts with water treatment and insulin production systems, followed by market-leading filling and closing machines. Once the cartridges have been inspected, the insulin pens are assembled on the fully automated assembly platform from Moeller Devicon, before they are packaged, serialized and aggregated. Many further components, such as CIP/SIP systems and equipment sterilizers, can be added to the line. "Depending on therapeutic area and dosage form, customers receive lines that are tailored exactly to their requirements, with ideally aligned machines and systems. At the same time, all new developments are based on pharmaceutical requirements," Treitel underlines.
Highly flexible line configurations
For ophthalmologic applications, Bosch showcases a Sigpack HSL horizontal flow wrapping machine, which is loaded with vial cards via a Sigpack LDF feedplacer. The eye drops, which have been filled with the blow-fill-seal technology, are packaged and hermetically sealed in aluminum compound film to secure products from water vapor and light exposure. An exemplary animation shows how liquid oral dosage forms such as cough syrup can be filled in glass and plastic bottles. Bosch also offers the suitable process technology for these types of medication, as well as the high purity media systems and product sterilizers that are required for after-treatment. Moreover, all line configurations can be flexibly combined with further inspection devices, handling equipment and secondary packaging machines. The requested serialization features are applied to the packaging before aggregation.
Comprehensive consulting and services
"Beyond machine technology, we support customers with market-specific expertise, as well as detailed project and integration competence," says Christian Treitel. With additional services and comprehensive consulting before, during and after start-up, Bosch ensures that all customer needs are satisfied. This also includes qualification and validation of the lines. Furthermore, the worldwide training platform Bosch Packaging Academy, which was founded in 2014, offers customers and employees a standardized knowledge pool for the entire Bosch Packaging Technology machine portfolio.
Bosch Packaging Services supports its customers with sophisticated maintenance concepts to achieve the highest machine availability with less downtime and reduced costs. Apart from conducting maintenance activities based on electronic protocols, Bosch offers services such as thermography and cleaning of control cabinets. A large range of modernization and technical audits, as well as remote services help customers to flexibly adapt their existing machines and lines to future market requirements.
Automation technology from Bosch Rexroth
Bosch has set the course for automation technology: the continuous system solution IndraMotion MLC from Rexroth offers a future-proof drive and control technology that also fulfills the growing demands for networked machines and systems on the basis of Open Core Engineering. This way, the automation technology rounds out Bosch's line competence. Bosch's technologies are on display at Achema in Frankfurt/Main, Germany, from 15 to 19 June, hall 3.1, booth C71.
Based in Waiblingen near Stuttgart, Germany, and employing 5,600 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact. Additional information is available online at www.boschpackaging.com
The Bosch Group is a leading global supplier of technology and services. According to preliminary figures, its roughly 290,000 associates generated sales of 48.9 billion euros in 2014. Its operations are divided into four business sectors: Mobility Solutions, Industrial Technology, Consumer Goods, and Energy and Building Technology. The Bosch Group comprises Robert Bosch GmbH and its more than 360 subsidiaries and regional companies in some 50 countries. If its sales and service partners are included, then Bosch is represented in roughly 150 countries. This worldwide development, manufacturing, and sales network is the foundation for further growth. In 2014, Bosch applied for some 4,600 patents worldwide. The Bosch Group's strategic goal is to deliver innovations for connected life. Bosch improves quality of life worldwide with products and services that are innovative and spark enthusiasm. In short, Bosch creates technology that is "Invented for life."
The company was set up in Stuttgart in 1886 by Robert Bosch (1861-1942) as "Workshop for Precision Mechanics and Electrical Engineering." The special ownership structure of Robert Bosch GmbH guarantees the entrepreneurial freedom of the Bosch Group, making it possible for the company to plan over the long term and to undertake significant up-front investments in the safeguarding of its future. Ninety-two percent of the share capital of Robert Bosch GmbH is held by Robert Bosch Stiftung GmbH, a charitable foundation. The majority of voting rights are held by Robert Bosch Industrietreuhand KG, an industrial trust. The entrepreneurial ownership functions are carried out by the trust. The remaining shares are held by the Bosch family and by Robert Bosch GmbH.
Additional information is available online at www.bosch.com, www.bosch-press.com,
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