Morphologically Directed Raman Spectroscopy Supports Identification of Particles in Mixed Populations
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Malvern Instruments Ltd
Enigma Business Park
Malvern Worcestershire, WR14 1XZ
Press release date: January 29, 2013
Malvern, UK: With the introduction of the Morphologi G3-ID system last year, Malvern Instruments is providing researchers with the ability to apply morphologically directed Raman spectroscopy to a range of different sample types. Such advanced particle analysis is proving valuable and highly effective in applications that include inhaled product characterization and pharmaceutical bioequivalence studies, bioequivalence for nasal sprays being referenced specifically in a talk given by the FDA at this year's IFPAC conference [January 22-25, 2013 Baltimore, MD, USA]. The use of morphologically targeted Raman spectroscopy has also been described in an independent article, as part of granulation studies, to provide the physical and chemical identities of particles in mixed populations .
By combining automated particle imaging with Raman spectroscopy, the Morphologi G3-ID offers a single platform for the measurement of particle size, shape and chemical identity. The technology involved enables independent characterization of individual components present within a blend or mixture, while the instrument itself is designed for automation and ease of use. Standard operating procedures control all aspects of the measurement from sample dispersion through to size, shape and chemical analyses, enabling automatic selection, targeting and chemical classification of 1000s of individual particles.
A comprehensive introduction to the Morphologi G3-ID can be downloaded from the Malvern website http://www.malvern.com/morphologi-g3-id-intro
 Justin Pritchard & Martin Warman; Advanced Particle Analysis Integrated Into Performance-directed Characterization; American Pharmaceutical Review, July 2012.
Malvern, Malvern Instruments and Morphologi are registered trademarks of Malvern Instruments Ltd
About Malvern Instruments
Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern's materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.
Our products reflect Malvern's drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.
Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com
Marisa Fraser, Malvern Instruments Inc.
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Alison Vines, Malvern Instruments Ltd
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