Malvern Presents New Analytical Approaches for Characterizing Inhalation Products
Share:
29 October 2008: Malvern, UK: As well as exhibiting at this year's Drug Delivery to the Lungs conference (DDL 19, 10-12 December 2008, Edinburgh, Scotland), Malvern Instruments will participate in the scientific poster sessions. Here the company will present two new studies demonstrating the application of the Morphologi G3 and Spraytec particle characterization systems to different aspects of inhaled product testing.
One study shows that the Morphologi G3 fully automated particle characterization system slashes the time taken to accurately and reproducibly quantify Foreign Particulate Matter (FPM) in pharmaceutical inhalation products. FPM is contaminating material introduced during the manufacturing process or generated by abrasion or shearing during device activation. Its presence in inhalation products is strictly regulated so measuring FPM levels is an important QC activity. The Morphologi G3 can successfully replace manual microscopy for quantifying FPM, reducing measurement times from around a day to less than one hour. Furthermore, the analysis provides detailed information on particle morphology that makes it easier to determine the contamination source.
In the second study, undertaken collaboratively with Melbourne Scientific and Copley Scientific, Malvern's Spraytec laser diffraction particle size analyzer was used to investigate the impact of rheological properties on nebulizer performance. Outputs from a breath-assisted jet nebulizer were examined under different breathing profiles, for a series of different viscosity solutions. The results show that structure in the fluid has a marked effect on the particle size and concentration of the delivered aerosol, providing valuable insight for optimising both device and formulation.
Malvern specialists will be available throughout the conference. For full details of Malvern's range of analytical systems visit www.malvern.com
About Malvern Instruments
Malvern Instruments provides a range of complementary materials characterization tools that deliver inter-related measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Analytical instruments from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to the latest nanomaterials and delicate macromolecules. A broad portfolio of innovative technologies is combined with intelligent, user-friendly software. These systems deliver industrially relevant data enabling our customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging).
Particle size distribution, particle shape information, zeta potential, molecular weight, chemical composition, and bulk materials properties can all be determined with instruments from the Malvern range. The company's laboratory, at-line, on-line and in-line solutions are proven in sectors as diverse as cement production and pharmaceutical drug discovery.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com
For press information, please contact:
Trish Appleton Kapler Communications
Knowledge Centre Wyboston Lakes, Great North Road
Wyboston, Bedfordshire, MK44 3BY, UK
Tel: +44 (0)1480 479280 Fax: +44 (0)1480 470343 trish@kapleronline.com
USA contact:
Marisa Fraser Malvern Instruments Inc.
117 Flanders Road, Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400 Fax: +1 508 768 6403 marisa.fraser@malvern.com
Please send sales enquiries to:
Alison Vines Malvern Instruments Ltd
Enigma Business Park, Grovewood Road Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456 Fax: +44 (0) 1684 892789 salesinfo@malvern.com
