ThomasNet News Logo
Sign Up | Log In | ThomasNet Home | Promote Your Business

Genedata at SLAS2014 Announces New Data Analysis Platform for Next-Gen Oncology Drug Discovery

Print | 
Email |  Comment   Share  

Genedata AG
Maulbeerstrasse 46
Basel, CH-4016
Switzerland



Press release date: January 20, 2014

AstraZeneca and Genedata will detail a data analysis platform for compound combination experiments in oncology and other therapeutic areas 
  
San Diego, Calif. – Genedata, a leading provider of advanced software solutions for drug discovery and life science research, today announced that at SLAS2014 it will showcase results from its collaboration with AstraZeneca on the data analysis of compound combination experiments. This collaboration created the new Genedata Screener® for Compound Combinations platform, which provides for high-throughput combination screening capabilities within AstraZeneca's Oncology iMed unit. Automating and standardizing the data analysis of combination screening experiments, Genedata Screener for Compound Combinations accelerates discovery of new compound combination therapies by enabling high-throughput combination profiling. The platform will be featured in a joint poster session, and Genedata Screener for Compound Combinations will be previewed in two tutorials and demonstrated at the 3rd Annual SLAS at the San Diego Convention Center (Booth #551; January 20-22).

Experiment Scope Extended in Single-Platform Solution
Genedata Screener is used by the majority of the top 25 global pharmaceutical companies as their main platform for the analysis and management of all plate-based screening data. Capitalizing on the open architecture  of Genedata Screener and its proven efficiency in a broad range of screening workflows, the Genedata collaboration with AstraZeneca extends Genedata Screener functionality to a new range of applications of increasing importance for innovative oncology research.

Identifying effective and disease-specific combinations of cancer therapies through in vitro cell-based assays requires industrial-scale screening.  As the number of tests increases exponentially with the number of compounds in a study, a high-throughput screening infrastructure with automated yet flexible analytical tools is needed for rapid profiling of even a modest number of drugs in combination studies. For example, testing all combinations of 30 compounds across 20 cell lines requires screening of over 9,000 384-well plates, which presents a computational challenge with weeks of data analysis. This data analysis bottleneck is removed by Genedata Screener for Combination Screening. It quickly analyzes screening results with standardized yet customizable parameter settings to calculate, combine, and visualize experimental data and identify the best combinations. Within hours versus weeks, researchers have scientifically validated results.

The new platform enables analysis of all experimental data generated throughout the process -- from raw instrument data to final synergy score calculations for all combinations in a study. While it offers an advanced degree of automation, efficiency and integration with an existing screening data infrastructure, Genedata Screener also provides interactive data quality assessment and continuous data review. Results scoring uses various published mathematical models (i.e. HSA, Loewe, Bliss), and new, yet reliable, methods for determining response surfaces deliver fast, accurate and robust assessments of synergistic effects.

"Our successful collaboration with AstraZeneca demonstrates our expertise in solving complex data analysis challenges, drives the development of Genedata Screener as the platform of choice for all plate-based screening data analysis, and shows how we create sustainable and cost-effective solutions for our customers," noted Dr. Othmar Pfannes, CEO of Genedata. "We are committed to a business model that delivers innovative data analysis procedures, enabling our customers to become more efficient in their research processes and maximizing the return on investments in their technology platforms."

SLAS Poster Session:
"Accelerating Discovery of Novel Drug Combination Therapies Using High-Throughput Combination Profiling - Challenges and Effective Solutions;" Eric Tang, Associate Principle Scientist, AstraZeneca; Stephan Heyse, Head of Genedata Screener, Genedata, et al.
SLAS Tutorials:
January 20; 2:00pm - 2:45pm: "Genedata Screener: Mastering complex screening technologies"
January 21; 2:00pm - 2:45pm: "Genedata Screener Compound Synergy Extension: Complex raw data to transparent results in less than 30 minutes"

About Genedata
Genedata transforms data into intelligence with a portfolio of advanced software solutions, which make research data accessible and understandable and research processes more efficient. These solutions are used worldwide by leading pharmaceutical, industrial, and agricultural biotechnology companies as well as academic research organizations. Genedata innovations enable scientific discovery that fights disease and improves health and quality of life worldwide. Founded in 1997, Genedata is headquartered in Switzerland, and has offices in Germany, Japan, and the US.

www.genedata.com 

Contacts:
Allison Kurz
Genedata
Marketing & Communications
Phone: +41 61 511 8459
communications@genedata.com

Jackie Thrasivoulos
Genedata
Public Relations
Phone: +1 508 380 6408
jackie.thrasivoulos@genedata.com

All product and service names mentioned are the trademarks of their respective companies.


Genedata AG 
Margarethenstrasse 38
4053 Basel, Switzerland 
Tel. +41 61 511 8400 
Fax +41 61 511 8484

Genedata Inc. 
750 Marrett Road
One Cranberry Hill, Suite 403
Lexington, MA 02421 
Tel. +1 781 357 4755 
Fax +1 781 357 4770

Genedata Inc. 
109 Stevenson Street
4th Floor
San Francisco, CA 94105 
Tel. +1 877 436 3872
Fax +1 415 970 6631

Genedata GmbH 
Lena-Christ-Strasse 50
82152 Martinsried, Germany 
Tel. +49 89 4581 9010 
Fax +49 89 4581 9015

Genedata KK 
1-7-11, Higashi-Gotanda
Shinagawa-Ku
Tokyo 141-0022, Japan 
Tel. +81 3 6721 7261 
Fax +81 3 6721 7262
www.genedata.com  
communications@genedata.com
Forward email
 
Genedata 
Margarethenstrasse 38 
Basel, 4053 Switzerland


Print | 
Email |  Comment   Share  
Contacts: View detailed contact information.


 

Post a comment about this story

Name:
E-mail:
(your e-mail address will not be posted)
Comment title:
Comment:
To submit comment, enter the security code shown below and press 'Post Comment'.
 



 See related product stories
More .....
 See more product news in:
Software
 More New Product News from this company:
Screening Software minimizes data analysis time.
Mass Spectrometry Software targets biopharma workflows.
Analytical Software automates biopharmaceuticals characterization.
Spectrometry Software enables integrated metabolomics analysis.
Biologics R&D Software supports development workflows.
More ....
| Featured Manufacturing Jobs
 Other News from this company:
GSK Implements Genedata Biologics as Antibody Discovery Platform
Genedata Biologics for Biopharma R&D at 10th Annual PEGS
New Genedata Screener for Surface Plasmon Resonance Co-developed with AstraZeneca Announced at 2014 Bio-IT World Conference & Expo
Genedata Showcases Integrated Analysis and Image Management Solution for Phenotypic Screening at 11th Annual HCA
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology Chooses Genedata Expressionist for Oncology Research
More ....
 Tools for you
Watch Company 
Company web site
More news from this company
E-mail this story to a friend
Save Story
Search for suppliers of
Scientific Software
Medical & Health Care Software
Data Analysis Software
Software
Join the forum discussion at:
Engineers Lounge


Home  |  My ThomasNet News®  |  Industry Market Trends®  |  Submit Release  |  Advertise  |  Contact News  |  About Us
Brought to you by Thomasnet.com        Browse ThomasNet Directory

Copyright © 2014 Thomas Publishing Company. All Rights Reserved.
Terms of Use - Privacy Policy



Error close

Please enter a valid email address